6. Transplant

Autograft

Allograft

Isograft

Xenograft

MHC ___________ encode for __________ such as ________

genes; proteins; HLA

MHC I encodes for _________________________________

antigen presentation in all nucleated cells

MHC I span the membrane of almost every ____________

nucleated cell

Class I mainly presents _______________ antigens to CD8 T cells

Endogenous (Ag that appears within the cell i.e. infected by organism)

Class I proteins include: __________________________

HLA-A, HLA-B, HLA-C

MHC II encodes for ____________ ____________ _________

Antigen Presenting Cells

MHC II is primarily found on ______ ______ ______

Antigen Presenting Cells ( Dendritic, monocytes, macrophages, B cells)

Class II mainly presents _______________ antigens to CD4 T cells

Exogenous (Ag present extracellularly i.e. ingested the organism)

Class II proteins include: ___________________

HLA-DR, HLA-DQ, HLA-DP

MHC III encodes for ____________, ______________, and ____________

complement, cytokines, other genes

HLA system is the strongest immunologic _____________ for successful allogenic organ transplants

barrier

HLA antigens exhibit a high degree of __________ ________________

allelic polymorphism

Hyperacute Rejections is an_____________ and _____________ mediated response

immediate and antibody

In Hyperacute Rejection recipient has _________________ antibodies reactive with donor tissue

pre-exisiting

Hyperacute Rejection leads to_______________ activation

complement

In Hyperacute Rejection, Thrombosis and occlusion of ______________ vessels

Can be prevented by:

graft

Prevented by:

• ABO matching

• Cross-matching donor and recipient

Acute Rejection is________ mediated immune response against foreign MHC

T cell

Acute Rejection can take __________ to _____________

weeks to months

In Acute Rejection, Inflammation and _____________ _______________ of graft vessels results

leukocyte infiltration

Acute Rejection is the_____________ common type

most

Chronic Rejection can take __________ to _____________

months to years

Chronic Rejection is the_________ cause of long-term failure of transplantation

major

Chronic Rejection is________ mediated immune response against foreign MHC

T cell

Chronic Rejection results in ______________ and ____________ of graft vessels leading to organ_____

thickening and fibrosis; ischemia (atrophy)

The most common GVHD is from __________ ____________ transplants

bone marrow

In GVHD ____________ T cells proliferate and attack _____________ tissue

Donor; Recipient

In GVHD, patients present with ______________, ___________, and _______________

diarrhea, rash, juandice

Types of Rejection summary chart

What 4 things will a transplant recipient be tested for?

1. ABO

2. HLA

3. CMV

4. Test for anti-HLA antibodies to eliminate unacceptable donors

DNA Inhibitors or Anti-proliferatives; How do these work?

What are the 2 common DNA Inhibitors or Anti-proliferatives named?

1.Methotrexate

2.Mycophenolic Acid (MPA)

T cell inhibitors help prevent ______________ rejection

allograft

Calcineurin inhibitors

mTOR inhibitors

Corticosteroids inhibit inflammation in what ways?