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VOCABULARY-style flashcards covering key terms and concepts from tissue biology.
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Tissues
A group of cells that usually have a common origin in an embryo and function together to carry out specialized activities.
Histology
The science that deals with the study of tissues.
Pathologist
A physician who specializes in laboratory studies of cells and tissues to assist diagnoses.
Epithelial tissue
Tissue that covers body surfaces, lines hollow organs and ducts, and forms glands.
Connective tissue
Tissue that binds, supports, protects organs; stores energy; transports substances.
Muscular tissue
Tissue composed of cells specialized for contraction and generation of force.
Nervous tissue
Tissue that detects changes and responds by generating electrical signals.
Cell junctions
Contact points between the plasma membranes of tissue cells.
Tight junction
Occluding junction that seals passageways between adjacent cells.
Adherens junction
Junction with a plaque that attaches membrane proteins to microfilaments; cadherins link cells.
Cadherin
Transmembrane glycoproteins that participate in adherens junctions.
Desmosomes
Junctions with plaques that connect intermediate filaments; resist tearing.
Intermediate filaments
Cytoskeletal fibers (e.g., keratin) attached to desmosomes.
Hemidesmosomes
Junctions that anchor cells to the basement membrane via integrins.
Integrin
Transmembrane glycoprotein in hemidesmosomes that links to the basement membrane.
Gap junctions
Intercellular channels formed by connexins/connexons allowing cell-to-cell communication.
Connexin
Transmembrane proteins that form gap junction channels.
Connexon
Hexameric channel formed by connexins in gap junctions.
Apical surface
Free, exposed surface of epithelial cells.
Basal surface
Surface that adheres to the basement membrane.
Basement membrane
Thin layer separating epithelium from underlying connective tissue.
Simple epithelium
Single layer of cells; functions in diffusion, osmosis, filtration, secretion, or absorption.
Pseudostratified epithelium
Epithelium that looks multi-layered due to nuclei at different levels; often ciliated.
Stratified epithelium
Two or more cell layers; provides protection against wear and tear.
Squamous epithelium
Flat, scale-like epithelial cells.
Cuboidal epithelium
Cube-shaped epithelial cells.
Columnar epithelium
Tall, column-like epithelial cells.
Transitional epithelium
Epithelium that changes shape (squamous to cuboidal) to stretch in organs like the urinary bladder.
Keratinized stratified squamous
Stratified squamous epithelium with surface keratin that is dead and protective.
Nonkeratinized stratified squamous
Stratified squamous epithelium with living surface cells; moist.
Simple squamous epithelium
Single layer of flat cells; suitable for diffusion/filtration.
Simple cuboidal epithelium
Single layer of cube-shaped cells; functions in secretion and absorption.
Simple columnar epithelium (nonciliated)
Single layer of nonciliated columnar cells with microvilli and goblet cells; secretes/absorbs.
Goblet cells
Unicellular glands that secrete mucus onto epithelial surfaces.
Microvilli
Finger-like extensions that increase surface area for absorption.
Cilia
Hair-like projections that move mucus or particles along surfaces.
Pseudostratified ciliated columnar epithelium
Pseudostratified epithelium with cilia and goblet cells; secretes mucus.
Pseudostratified nonciliated columnar epithelium
Pseudostratified epithelium without cilia or goblet cells; absorption.
Glandular epithelium
Epithelium that forms the secreting portions of glands.
Endocrine glands
Glands that secrete hormones directly into the bloodstream (ductless).
Exocrine glands
Glands that secrete products into ducts onto surfaces.
Goblet cell (unicellular gland)
Unicellular exocrine gland secreting mucus onto epithelia.
Multicellular glands
Glands composed of many cells forming ducts and secretory portions.
Unicellular glands
Glands composed of a single cell, such as goblet cells.
Glandular epithelium
Epithelium specialized for secretion in glands.
Mucous membranes
Lining of cavities that open to the exterior; contain epithelium and lamina propria.
Lamina propria
Areolar connective tissue underlying mucous membranes.
Serous membranes
Membranes lining cavities not open to exterior; consist of areolar tissue and mesothelium.
Parietal serous membrane
Serous membrane attached to cavity walls.
Visceral serous membrane
Serous membrane covering organs within the cavity.
Pleura
Serous membrane lining the thoracic cavity and covering lungs.
Pericardium
Serous membrane lining the heart cavity and covering the heart.
Peritoneum
Serous membrane lining the abdominal cavity and covering abdominal organs.
Cutaneous membrane
Skin; the largest membrane, with epidermis and dermis.
Synovial membrane
Membrane lining joint cavities without epithelium; secretes synovial fluid.
Synoviocytes
Cells lining synovial membranes that secrete synovial fluid.
Ground substance
Material between cells and fibers; can be fluid, gelatinous, semifluid, or calcified.
Extracellular matrix
Material between cells and fibers secreted by connective tissue cells.
Proteoglycans
Glycosaminoglycan proteins that trap water in the matrix.
Glycosaminoglycans (GAGs)
Polysaccharides like hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate.
Hyaluronic acid
Viscous, slippery substance in ground substance; binds cells and lubricates joints.
Chondroitin sulfate
GAG providing support and adhesiveness in cartilage, bone, skin, and vessels.
Dermatan sulfate
GAG found in skin, tendons, vessels, and heart valves.
Keratan sulfate
GAG found in bone, cartilage, and cornea.
Fibronectin
Adhesion protein linking ground substance to collagen and cells.
Collagen fibers
Strong fibers resisting tension; provide tensile strength.
Elastic fibers
Fibers composed of elastin and fibrillin that allow stretch and recoil.
Reticular fibers
Fine collagen fibers forming networks to support organs.
Fibroblasts
Cells that synthesize fibers and ground substance.
Macrophages
Phagocytic cells derived from monocytes; engulf pathogens and debris.
Plasma cells
Cells derived from B lymphocytes that secrete antibodies.
Mast cells
Cells that release histamine and participate in inflammatory responses.
Adipocytes
Fat cells that store triglycerides.
Neutrophils
White blood cells that migrate to infection and perform phagocytosis.
Eosinophils
White blood cells active in parasitic infections and allergic responses.
Areolar connective tissue
Loose connective tissue that acts as packing material around other structures.
Adipose tissue
Loose connective tissue that stores fat; white and brown types exist.
Reticular connective tissue
Loose connective tissue with a reticular fiber network forming stroma.
Dense regular connective tissue
Dense connective tissue with collagen fibers aligned in parallel; forms tendons and ligaments.
Dense irregular connective tissue
Dense tissue with irregular collagen fiber arrangement; provides multi-directional strength.
Elastic connective tissue
Dense tissue with many elastic fibers; allows stretching and recoil.
Mesenchyme
Embryonic connective tissue; precursor to other connective tissues.
Mucous connective tissue
Embryonic connective tissue found in the umbilical cord.
Cartilage
Semi-rigid connective tissue with collagen and proteoglycans.
Hyaline cartilage
Glassy cartilage with fine collagen; most common cartilage.
Fibrocartilage
Strong cartilage with thick collagen fibers; lacks a perichondrium.
Elastic cartilage
Cartilage with elastic fibers; maintains shape.
Perichondrium
Dense irregular connective tissue surrounding cartilage.
Chondrocyte
Cartilage cell located in lacunae.
Lacuna
Small space containing a mature cell within cartilage or bone.
Osteon (Haversian system)
Basic unit of compact bone containing lamellae, lacunae, canaliculi, and a central canal.
Lamellae
Concentric sheets of extracellular matrix in osteons.
Lacuna (bone)
Small space housing an osteocyte within bone.
Canaliculi
Small channels that connect lacunae and allow nutrient/waste exchange.
Central (Haversian) canal
Passage for blood vessels and nerves through an osteon.
Osteocytes
Mature bone cells located in lacunae.
Endosteum
Membrane lining the inner surfaces of bone cavities.
Compact bone
Dense bone tissue organized into osteons.
Spongy bone
Bone tissue with trabeculae and spaces for red marrow.
Trabeculae
Bar-like structures in spongy bone forming a lattice.