Acyl Chloride

what is the general formula for Acyl Chloride ?

Cn H2n - 1 OCl

what is the functional group of acyl chloride ?

COCl

fun fact

Acyl chloride acts like carboxylic acid , but more reactive

what is the name CH3CH2CH( CH3 ) CH ( CH3 ) COCl ? + Draw

2-3 dimethyl - pentanoyl chloride

Name this CH3CH2COBr + Draw the skeletal formula

Propanol bromide

Name this CH3CH2CH (CH3 ) COCl + Draw the skeletal formula

2 methyl Butanoyl Chloride

what is the suffix for acyl chloride ?

oyl chloride

Reactivity of acyl chloride

Very reactive due to polar groups of oxygen and chloride, compared to hydrogen - dipole

what is the mechanism or reaction called for Acyl chloride ?

Nucleophilic addition - elimination or Acylation reactions

What does the reaction occurs with ?

Water, alcohols , ammonia , primary amines

Acyl chloride reacts with water generates ?

Carboxylic acid

what are the observations of acyl chloride + water → ?

Vigorous reactions with cold water

Misty fumes released - From HCL from the kicked out chlorine and the hydrogen from water

what is the reaction called ?

Substitution

Draw the reaction of Ethanoyl l chloride + water → ?

Ethanoic acid + HCl

Acyl chloride reacts with alcohols generates ?

Esters

what are the observations of acyl chloride + alcohol → ?

Vigorous reactions at room temperature + Misty fume

Fun fact

This react is already at equilibrium

Draw ( displayed formula ) the reaction of Ethanoyl chloride + alcohols → ?

Methyl ethanoate

Acyl chloride reacts with ammonia generates what ?

Generates amides

what is the suffix of amide

ide

what are the observations of this reaction acyl chloride + ammonia ?

Vigorous reaction at room temperature.

Misty fumes released

Draw a displayed formula of this reaction Ethanol chloride + Ammonia → ?

Ethanol chloride + Ammonia → Ethanamide + HCl

Any chloride reacts with primary amines generates what ?

Reacts to generates N - substituted amides

what are the observations of this reaction acyl chloride + primary amides

Vigorous reaction at room temp

Misty fumes released

Draw a displayed formula of this reaction Ethanoyl chloride + methylamine → ?

Ethanoyl chloride + methylamine → N - methylethanamide + HCl

Amine NH2

Amide NH2 + C = O

does the amide takes priority over halogen ?

yes

name this and draw the displayed formula

Propanamide

Name this and draw the displayed formula

2 bromobutanamide

name this and draw the displayed formula

3 bromo 4 methyl pentanamide

name this and draw the displayed formula

4ethylhexanamide

draw a primary , secondary and tertiary amine

Draw aa quaternary amine

name this

Propylanamine

name this

Diethylammine

amine are weird why ?

They are derived from carbonyl

what is the suffice for amide

• ide

what is the prefix amide

acyl group R - C= O

Name this

Methanamide

name this

name this

N - methylpropanamide

what is a substitutes amides

one of the halogens is substituted instead by some kind of R group

name this and draw the displayed formula

name this and draw the displayed formula

N ethylpropanamide

The mechanism of acyl chloride what is the name of the mechanism / reaction

Nucleophilic addition elimination

Stage 1 of mechanism

Addition of the nucleophile onto the carbon by breaking of the carbonyl both with oxygen

Elimination of the chlorine ( halogen ) atom

Stage 2 of mechanism

Nucleophile will be positive as too many bonds as the hydrogen leaves .

draw a mechanism of methyl chloride reacts with a Nu - H

Draw a mechanism of ethanol chloride with methanol