Antigen/Antibody categories

🔁 Antigens That Exhibit Dosage

Mnemonic:

Really Keen Duffy Kids Make Lovely Dosage

• Rh

• Kell

• Duffy

• Kidd

• MNSs

• Lutheran

💡 Strategy:
Remember these 6 as “dosage expressers” — everyone else is a NO by default.

🚫 Antigens That Do Not Exhibit Dosage

🧠 Mnemonic:

A Pretty Loose system shows no dosage

• ABO

• P/Glob

• Lewis

❄ IgM / Cold-Reactive / Naturally Occurring

🧠 Mnemonic: "All My Pretty Little Ants"

• ABO

• M/N

• P1

• Lewis

• Anti-Lua

💡 Strategy: These are the antibodies that “just show up” — no exposure needed.

🔥 IgG / Warm-Reactive / Immune Stimulated

🧠 Mnemonic:

Really Killer Dudes Kill Some Pretty Ladies

• Rh

• Kell

• Duffy

• Kidd

• S/s

• anti-P (PP1Pk/P2)

• anti-Lub

💡 Strategy: These antibodies require exposure (transfusion, pregnancy). If it's IgG and warm-reactive, assume immune-stimulated unless it’s a weird exception (like anti-M sometimes).

🧬 Binds Complement

🧠 Mnemonic: "All Killer Systems Like Lysis"

• ABO

• Kidd

• S/s

• Lewis

• Lub

💡 These are the lysis-prone systems — the ones that can fix complement and potentially lead to intravascular hemolysis (esp. ABO and Kidd).

🚫 Does Not Bind Complement

🧠 Use exceptions approach:

• Rh

• Kell

• Duffy (rarely)

• M/N

• Anti-PP1Pk

🧠 Mnemonic (more awkward):

Really Kind Duffy Moms Prefer No Compliment

💡 Flip strategy: Memorize the complement-binders (ABO, Kidd, etc.) — and assume the rest don't unless specifically told otherwise.

💉 Causes HTRXN

🧠 Mnemonic:\

All Really Dangerous Kidds Kill Some People

• ABO

• Rh

• Duffy

• Kell

• Kidd

• S/s

• P/Glob

💡 P/Glob here refers to anti-PP1Pk — hemolytic, binds complement

🚫 Does Not Cause HTRXN

• Lewis

• Lutheran

🧠 Mnemonic: "Lewis and Luther just chill."

💡 Lewis fixes complement, but doesn't hemolyze. Lutheran may cause jaundice, not true HTRXN.

👶 Causes HDN

🧠 Mnemonic

All Really Dangerous Kidds Kill Small

• ABO

• Rh

• Duffy

• Kell

• Kidd

• S/s

💡 Remember: Kell is severe, Kidd is mild, S/s is rare

Exception-based recall: P/Glob, Lewis, Lutheran = do not cause HDN

🚫 Does Not Cause HDN

🧠 Mnemonic: "Please Leave Little ones alone."

• P/Glob

• Lewis

• Lutheran