ANS DRUGS [PCOL PHLE]

adrenaline

epinephrine aka

anaphylaxis

inc. histamine release IgE

anaphylactoid rxn

inc. histamine release Non-IgE

lidocaine

epinephrine is used as local vasocotrictor when combined w/

dipivefrin

prodrug of epi used in mgtmt of glaucoma

a2 agonist, b-blockers, diuretics (CAIs)

dec. inflow (anti glaucoma agents)

cholinomimetics, EPI, prostaglandin analogues

inc. outflow (anti glaucoma agents)

noradrenaline, levarterenol

2 other names of norepinephrine

oliguria

low urine output

anuria

no urine output

D1

low dose (0.5-5 mcg/kg/min) dopamine receptor

Beta

moderate dose (5-10 or 15 mcg/kg/min) dopamine receptor

alpha

high dose (>10 or 15 mcg/kg/min) dopamine receptor

vasoconstriction and mydriasis

2 effects of a1 agonists

oxymetazoline

intranasal tx of nasal congestion

tetrahydrozoline

eyedrops treatment for red eyes

phenylephrine

eyedrop used for dilating pupil

rhinitis medicamentosa

local toxic effect of a1 agonist (intranasal)

3

rhinitis medicamentosa occurs when oxymetazoline is used for more than __ days

hypertention, urine retention, tolerance

3 toxic effects of systemic a1 agonist (IV, PO)

5

systemic a1 agonist (IV, PO) tolerance occurs when used for more than ___ days

apraclonidine, brimonidine

a2 selective used as antiglaucoma

methyldopa, clonidine, guanabenz, guanfacine

a2 selective used as antihypertensives

aldomet

methyldopa BN

catapress

clonidine BN

Methyldopa

used in HTN pregnancy

clonidine

used for hypertensive crisis

true

T/F- methyldopa makes coombs test positive (hemolytic anemia)

vasoconstriction

initial effect of clonidine (transient)

vasodilation

final effect of clonidine (lasting)

rebound HTN

toxic effect of clonidine

false, only the antibodies

True or False: Coombs test will reflect hepatotoxicity?

isoproterenol/ isoprenaline

alt. for shock states and acute HF

tachyphylaxis

toxicity of isoproterenol

isoproterenol/ isoprenaline

beta-nonselective agonists

dobutamine

B1 selective agonist

dobutamine

1st line for cardiogenic shock/ mgt. of acute HF

bronchodilator, tocolytic

2 classes of b2 SELECTIVE agonist

salbutamol/albuterol, terbutaline, metaproterenol, pirbuterol

SABA drugs

salmeterol, formoterol, bambuterol, indacaterol

LABA drugs

tocolytic

tx of premature labor

tyramine

D/I with MAOIs——> HTNsive crisis

ephedrine

from ma huang

amphetamine, atomexetine

alternatives for adhd

methylphenidate

1st line for adhd

modafinil

1st line for narcolepsy

phentermine, phenmetrazine

anorexiants

cocaine

only vasoconstrictor local anesthetic

sibutramine

use for management of obesity