Cellular Movement Flashcards

Flashcards about cell movement, adhesion molecules, HEVs, lymphocyte recirculation, leukocyte migration, selectins, integrins, chemokines, and T cells.

Migration/Recruitment

The general leukocyte movement from blood into tissues.

Homing

Going from blood to a specific site of inflammation or infection.

Recirculation

Going from blood, secondary lymphoid organs back into the blood.

Adhesion Molecules

Adhering leukocytes to endothelial cells.

Selectins

Expressed on plasma membranes, carbohydrate-binding, mediate initial low-affinity binding to endothelial cells, expression induced by cytokines.

P Selectin

Found on the endothelium and activated by histamines, interacts with ligands on neutrophils, monocytes, and T cells.

E Selectin

On endothelial cells, upregulated by TNF and interleukin-1, interacts with neutrophils, monocytes, T cells, and B cells.

L Selectin

The selectin itself is on the cells (neutrophils, monocytes, T cells), and its ligands are on HEVs (high endothelial venules).

ICAM1

Expressed on endothelial cells, interacts with LFA-1 on neutrophils.

LFA1

Expressed on neutrophils, monocytes, T cells, interacts with ICAM-1 on endothelial cells.

HEVs

High endothelial venules; structures in lymph nodes where naive T cells bind, allowing fluid and antigen-presenting cells to move through.

CCR7

A chemokine receptor found on naive T cells that recognizes high concentrations of CCL19 and CCL21.