Immunofluorescence Assay

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19 Terms

1
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ANA definition

antinuclear antibody

2
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ANA substrate

Hep-2 cells (from rat)

3
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Elevated ANA titers diseases (7)

  • SLE

  • RA

  • MCTD

  • scleroderma

  • dermatomyositis

  • malignancies

  • hypersensitivity

4
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Lowered ANA titers seen in (3)

  • aging

  • chronic hepatitis

  • some viral diseases

5
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ANA patterns

speckled

homogeneous

centromere

nucleolar

peripheral

6
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Homogeneous ANA pattern Ab

anti-histone

  • dsDNA

  • chromatin

7
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Speckled ANA pattern Ab

anti-nonhistone

  • SSa/SSb

  • Sm

  • RNP

    • Scl-70

8
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Centromere ANA pattern Ab

anti-centromere B

9
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Homogeneous ANA diseases

SLE

10
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Speckled ANA diseases

SLE

SS

scleroderma

MCTD

11
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Nucleolar ANA diseases

SLE

SS

scleroderma

12
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Centromere ANA diseases

CREST scleroderma

13
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Peripheral ANA diseases

SLE

CREAST scleroderma

14
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<p><span>ANA pattern?</span></p>

ANA pattern?

centromere

15
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<p>ANA pattern?</p>

ANA pattern?

centromere

16
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<p>ANA pattern?</p>

ANA pattern?

speckled

17
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<p>ANA pattern?</p>

ANA pattern?

homogeneous

18
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term image

homogeneous

19
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