pharmacologic principles

where can metabolism also occur

small intestine

lungs

mucosa

kidney

brain

skin

what can the liver also turn drugs into

inactive

more soluble

more potent

less active

prodrug

cyp450

enzymes in liver that cleans up 25% of the drug

first pass effect determines

dosing

excretion can also happen in

breast milk

expiration

sweat

saliva

half life

time it takes for 50% of drug to be eliminated

what is half life affected by

dme

steady state

amount in = amount out

pharmacodynamics

what the drug does to the body

agonist

each receptor produces a specific effect

antagonist

blocks the agonist action

antagonist overtime

more sensitive

agonist overtime

less sensitive

pharamcotherapeutics

use of drugs to prevent and treat diseases

acute

for short term

maintenance

long term

supplemental

give body something it is missing

palliative

decrease symptoms for comfort

supportive

help body while it heals

treatment

fix an existing problem

prohylatic

fix a problem before it occurs

empiric

take med before getting results of culture