13 - DDS LAB

What property does chitosan exhibit?

Muco-adhesive

Chitosan acts on which epithelial feature?

Tight junctions

Common use of chitosan-based nanomaterials

Continued drug release

Epithelia targeted by chitosan

Buccal, intestinal, nasal, eye, pulmonary

Alginate polymer type

Anionic mucoadhesive

Alginate mucoadhesive strength

Greater than cationic/neutral polymers

Sublingual nanoparticle with alginate

Nicotinamide

Effect of alginate nanoparticles

High bioavailability

Xanthan gum producer organism

Xanthomonas campestris

Xanthan gum type

Polyanionic polysaccharide

Xanthan gum toxicity

Non-toxic

Xanthan gum irritation

Non-irritating

Effect of xanthan thiolation

Increased buccal adhesion

Primary use of xanthan gum

Pharmaceutical excipient

Primary use of cellulose

Drug delivery systems

Nanocellulose benefits

High loading/binding capacity

Nanocellulose properties

High surface area, high polymerization

Liposome discoverer

Alec Bangham

Year liposomes discovered

1960

Liposome composition

Phospholipids and steroids

Liposome size range

50–450 nm

Liposome drug compatibility

Hydrophilic and hydrophobic

Liposome properties

Biocompatible, biodegradable

Liposome benefits

Improves stability and biodistribution

Liposome types

Conventional, PEGylated, Theragnostic, Ligand-targeted

Polymeric micelle composition

Amphiphilic block copolymers

Polymeric micelle structure

Core-shell

Polymeric micelle core function

Holds hydrophobic drugs

Polymeric micelle shell function

Water solubility and core stability

Example drugs in micelles

Camptothecin, docetaxel, paclitaxel

Dendrimer structure

Highly bifurcated, monodisperse, 3D

Inorganic nanoparticle types

Silver, gold, iron oxide, silica

Silver nanoparticle activity

Antimicrobial

Gold nanoparticle uses

Bio-imaging, receptor detection, endocytosis study

Iron oxide nanoparticle use

MRI contrast agents

Silica nanoparticle uses

Diagnostics, SERS, drug delivery, photothermal therapy

Nanocrystal composition

Pure solid drug particles

Nanocrystal size range

Below 1000 nm

Top-down nanocrystal methods

Sonocrystallization, precipitation, vortex mixing

Bottom-up nanocrystal method

Grinding with high-pressure homogenization

Metallic nanoparticle function

Bind to antibodies, drugs, ligands

Quantum dot type

Semiconductor nanocrystals

Quantum dot size range

2–10 nm

Quantum dot property dependency

Size-dependent

Nanoparticle biopolymer sources

Plants, animals, microbes, marine

Biopolymer classification

Polysaccharides and proteins