What is fatty acid catabolism?

What are the sources of fatty acids for catabolism?

• fats consumed in diet

• fats stored in adipose tissue

• fats synthesised in one organ and exported

What are the key organs in fatty acid catabolism?

• liver

• heart

• resting skeletal muscle

How are lipids transported?

• lipoprotein particles circulate in blood

  • apolipoproteins and lipids

• several classes of lipoproteins

• apolipoproteins act as signals

  • cellular uptake

  • metabolism

What is the fat of fatty acids in the cell?

• fatty acids <12 carbons transport into mitochondria

• fatty acids >14 carbons undergo 3 enzymatic reactions

  • carnitine shuttle

    • reaction 1 - acetyl coA synthases

    • reaction 2 - attached to carboxyl group of canitine = fatty acyl-carnitine

    • reaction 3 - fatty acyl group transferred from carnitine to CoA

How do you calculate the number of cycles?

number of carbons/ 2 - 1

How is the number of ATP calculated?

For every molecule of FADH₂, 1.5x ATP

For every molecule of NADH, 2.5x ATP

What enzyme is used when the acid has a double bond?

flip the acid into trans configuration using enoyl-CoA isomerase