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Biology
The scientific study of living organisms.
Cell Theory
Concept stating that all living organisms are composed of cells and that all cells arise from pre-existing cells.
Reductionist Biology
Physico-chemical approach that explains life processes by analyzing cells in molecular terms.
Cell
Fundamental structural and functional unit of all living organisms.
Unicellular Organism
A living organism composed of a single cell capable of independent existence.
Multicellular Organism
An organism composed of many cells that divide labor among specialized cell types.
Anton van Leeuwenhoek
First person to observe and describe live cells using a microscope.
Robert Brown
Scientist who discovered the cell nucleus (1831).
Matthias Schleiden
Botanist who proposed that all plants are made of cells.
Theodor Schwann
Zoologist who stated that animals are made of cells; co-formulated cell theory.
Rudolf Virchow
Pathologist who added that cells arise only from pre-existing cells—“Omnis cellula e cellula.”
Prokaryote
Cell lacking a membrane-bound nucleus and organelles; e.g., bacteria.
Eukaryote
Cell with a nucleus enclosed by a membrane and numerous membrane-bound organelles.
Cytoplasm
Semi-fluid matrix inside the cell where metabolic reactions occur.
Organelle
Specialized sub-cellular structure performing a specific function.
Ribosome
Non-membranous organelle that synthesizes proteins; 70S in prokaryotes, 80S in eukaryotes.
Centrosome
Animal-cell organelle containing a pair of centrioles; organizes spindle and basal bodies.
Mycoplasma
Smallest known prokaryotic cells; lack a cell wall.
Bacteria
Prokaryotic microorganisms with shapes such as bacillus, coccus, vibrio, and spirillum.
Glycocalyx
Outermost gelatinous layer of bacterial cell envelope; may form slime layer or capsule.
Cell Wall
Rigid outer layer in plants, fungi, and most bacteria that provides shape and protection.
Plasma Membrane
Selectively permeable phospholipid bilayer forming the cell’s boundary.
Mesosome
Infolding of prokaryotic plasma membrane involved in respiration and DNA distribution.
Plasmid
Small circular DNA molecules in bacteria that confer extra traits like antibiotic resistance.
Flagellum (Prokaryotic)
Long filamentous appendage enabling bacterial motility; composed of filament, hook, basal body.
Pilus
Elongated tubular surface structure in bacteria used for conjugation or attachment.
Fimbriae
Short bristle-like bacterial appendages that help in adhesion to surfaces.
Inclusion Body
Reserve material granule (e.g., glycogen, phosphate) lying free in prokaryotic cytoplasm.
Cell Envelope
Three-layered structure of bacteria: glycocalyx, cell wall, and plasma membrane.
Gram-Positive Bacteria
Bacteria with thick peptidoglycan cell wall that retain Gram stain.
Gram-Negative Bacteria
Bacteria with thin peptidoglycan and outer membrane; do not retain Gram stain.
Fluid Mosaic Model
Singer & Nicolson description of cell membrane as a fluid lipid bilayer with floating proteins.
Passive Transport
Movement of molecules across membrane along concentration gradient without energy input.
Osmosis
Diffusion of water through a selectively permeable membrane from high to low water potential.
Active Transport
Energy-requiring movement of substances against concentration gradient (e.g., Na⁺/K⁺ pump).
Endomembrane System
Coordinated group of organelles: ER, Golgi, lysosomes, and vacuoles.
Endoplasmic Reticulum (ER)
Network of membranous tubules; divides intracellular space into luminal and cytoplasmic compartments.
Rough ER (RER)
ER with ribosomes attached; synthesizes and transports proteins.
Smooth ER (SER)
ER lacking ribosomes; synthesizes lipids and steroid hormones.
Golgi Apparatus
Stack of flattened cisternae that modifies, packages, and sorts proteins and lipids.
Cis Face (Golgi)
Receiving side of Golgi apparatus where ER-derived vesicles fuse.
Trans Face (Golgi)
Maturing side of Golgi apparatus where processed vesicles bud off.
Lysosome
Single-membrane vesicle rich in hydrolytic enzymes for intracellular digestion.
Vacuole
Membrane-bound cavity (tonoplast) storing water, ions, or waste; large in plant cells.
Mitochondrion
Double-membrane organelle generating ATP via aerobic respiration; “powerhouse” of cell.
Crista
Fold of inner mitochondrial membrane that increases surface area for ATP production.
Plastid
Double-membrane plant organelle containing pigments or storage materials.
Chloroplast
Green plastid with chlorophyll; site of photosynthesis.
Thylakoid
Flattened membrane sac inside chloroplast where light reactions occur.
Granum
Stack of thylakoids within a chloroplast.
Stroma
Fluid matrix of chloroplast containing enzymes, DNA, and ribosomes.
Chromoplast
Plastid containing carotenoid pigments that impart yellow, orange, or red color.
Leucoplast
Colorless plastid specialized for storage (starch, oil, or protein).
Cytoskeleton
Network of microtubules, microfilaments, and intermediate filaments providing shape and movement.
Microtubule
Hollow protein filament composed of tubulin; forms spindle, cilia, flagella scaffold.
Microfilament
Thin filament of actin involved in cell motility and shape changes.
Cilium
Short hair-like projection moving fluid or the cell in a coordinated manner.
Flagellum (Eukaryotic)
Long whip-like projection enabling cell movement; shows 9+2 microtubule arrangement.
Axoneme
Core of cilia/flagella with 9 peripheral doublets and 2 central microtubules (9+2).
Basal Body
Centriole-derived structure anchoring cilium or flagellum to the cell.
Centriole
Cylindrical structure of nine triplet microtubules; forms spindle and basal bodies.
Nucleus
Double-membrane organelle housing DNA and controlling cellular activities.
Nuclear Envelope
Double membrane surrounding nucleus; outer layer continuous with RER.
Nuclear Pore
Opening in nuclear envelope allowing selective exchange of RNA and proteins.
Nucleolus
Dense, non-membranous nuclear body where rRNA synthesis and ribosome assembly occur.
Chromatin
DNA-protein complex in interphase nucleus that condenses into chromosomes during division.
Chromosome
Compact, visible DNA-protein structure formed during cell division.
Centromere
Primary constriction of chromosome where sister chromatids are joined.
Kinetochore
Protein disc on centromere where spindle fibers attach during mitosis.
Metacentric Chromosome
Chromosome with centromere in the middle producing equal arms.
Submetacentric Chromosome
Chromosome with centromere slightly off-center creating unequal arms.
Acrocentric Chromosome
Chromosome with centromere near one end resulting in a very short arm.
Telocentric Chromosome
Chromosome with centromere at the terminal end; essentially one arm.
Microbody
Small enzyme-containing vesicle such as peroxisome present in cytoplasm.