IPS1 - [Suppositories] - Preparation, Packaging, And Storage

Proverbs 16:3

● Hand Rolling and Shaping

● Compression Method

● Fusion Method (Molding from a Melt)

Methods of Preparation of Suppositories

Hand Rolling and Shaping

[METHODS OF PREPARATION FOR SUPPOSITORIES]

This is the OLDEST and SIMPLEST method.

Hand Rolling and Shaping

[METHODS OF PREPARATION FOR SUPPOSITORIES]

This involves ROLLING the suppository into the desired shape then the mass is then rolled into a CYLINDRICAL rod of desired length and diameter.

Compression Method

[METHODS OF PREPARATION FOR SUPPOSITORIES]

A method where the COLD MASS of the base containing the drug is COMPRESSED into suppositories by using compression into the desired shape.

Compression Method

[METHODS OF PREPARATION FOR SUPPOSITORIES]

This method avoids heat by forcing the mixture into a mold under pressure.

Compression Method

[METHODS OF PREPARATION FOR SUPPOSITORIES]

This method causes entrapment of air, causing OXIDATION of suppository ingredients.

Fusion Method

[METHODS OF PREPARATION FOR SUPPOSITORIES]

Most frequently used method in both SMALL and LARGE scale.

Fusion Method

[METHODS OF PREPARATION FOR SUPPOSITORIES]

This is also known as MOLDING FROM A MELT (drug is dispersed into the melted base).

Cocoa Butter-Based Suppositories

[PACKAGING]

INDIVIDUALLY wrapped in foil or plastic to prevent sticking

Glycerin or Glycerinated Gelatin Suppositories

[PACKAGING]

Packaged in TIGHTLY CLOSED containers to prevent moisture loss

Light-Sensitive Drugs

[PACKAGING]

INDIVIDUALLY wrapped in OPAQUE materials (metallic foil or opaque plastic)

● Metallic foil

● Opaque plastic

[PACKAGING]

Light-Sensitive Drugs are individually wrapped in OPAQUE materials like ___

Cocoa Butter-Based Suppositories

[STORAGE]

These should be REFRIGERATED

Glycerin or Glycerinated Gelatin Suppositories

[STORAGE]

Stored at CONTROLLED room temperature

PEG-Based Suppositories

[STORAGE]

Stored at usual ROOM temperature WITHOUT the requirement of refrigeration

High Humidity

[STORAGE]

Suppositories stored in (low, high) humidity may absorb moisture and become SPONGY or swollen.

Extreme Dryness

[STORAGE]

Suppositories stored in (low, extreme) dryness may lose moisture and become BRITTLE or cracked.