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appearance
behavior
speech
mood
affect
thought process
thought content
perception
insight
judgment
cognition
core components of a mental status exam
mood: pt's subjective emotional state
affect: clinician's objective assessment of emotional expression
differentiate mood and affect
thought process: organization and flow
thought content: delusions, obsessions, phobias, suicidal or homicidal ideation
differentiate thought process and though content
awareness of illness and need for treatment
what is insight in a MSE?
Distinguishes psychiatric vs neurologic vs medical causes
Helps identify emergent risks (suicidality, psychosis, delirium)
Tracks changes over time (baseline vs follow-up)
Provides objective documentation
why does a MSE matter clinically?
Grooming, hygiene, dress, posture, eye contact
assessment of appearance includes
DSM-V
the standardized classification system used to diagnose mental disorders.
1. symptom clusters (not single findings)
2. duration and severity
3. functional impairment (must cause distress)
4. exclusion criteria (rule out medical)
core principles of diagnosing a psychiatric disorder
1.History + MSE
2. Identify symptom pattern
3. Apply DSM-5 criteria
4. Rule out medical/substance causes
5. Assign diagnosis (and specifiers if applicable)
steps to diagnose a psychiatric illness
-diagnostic criteria
-duration requirements
-severity specifiers
-course specifiers
-associated features
-prevalence and risk factors
-comoribidity
specific components to a DSM V diagnosis
You do not diagnose from the MSE alone.The MSE provides evidence; the DSM-5 provides criteria.
can you diagnose based on MSE alone?
Major depressive disorder
Bipolar disorder
Schizophrenia
Substance use disorders
Anxiety/PTSD
psychiatric disorders increasing risk of suicide
prior suicide attempt
what is the strongest predictor of suicidality risk?
Male sex (higher completion)
Female sex (higher attempts)
differetiate trends in males vs females in suicide risk
Suicidal ideation with plan, intent, or means
Hopelessness
Command hallucinations
Agitation or severe anxiety
Sudden calm after distress (red flag)
acute warning signs of suicidality
"Are you thinking about harming yourself?"
"Do you have a plan?"
"Do you have access to the means?"
"Have you tried before?"
"What keeps you alive?"
key questions to ask to assess for suicide risk
active plan and intent
-access to lethal means
-psychosis or intoxication
patient presentation with the highest suicide risk
1. safety first: place on 1:1 observation, remove lethal means
2. involuntary hold if imminent risk
3. med and psych stabilization
immediate management of a suicidal patient
only if low risk with strong support and follow-up
indication for outpatient psychiatry in suicide risk
delirium
Fluctuating attention, acute onset
Alcohol, cocaine, meth, LSD
substance intoxications/withdrawals causing hallucinations
Déjà vu, automatisms
neuro symptoms associated with temporal lobe seizures
primary psychosis
Gradual onset hallucinations, organized delusions
schizophrenia
Bizarre, fixed delusions is most associated with
mood disorder with psychosis
mood congruent delusions is most indicative of
disorganized thinking
define delirium
dementia
paranoid delusions, gradual
delusions
false beliefs held by a person who refuses to accept evidence of their falseness
I WATCH DEATH
Infection (UTI, pneumonia, sepsis)
Withdrawal (EtOH, benzos)
Acute metabolic (Na, Ca, glucose)
Trauma
CNS pathology
Hypoxia
Drugs/toxins
Endocrine (thyroid, adrenal)
Acute vascular
Thiamine deficiency (Wernicke)
Heavy metals
common medical causes of confusion/altered consciousness (THINK DELIRIUM FIRST)
alcohol withdrawal
violent or agitated behavior + tremor, autonomic instability
benzos
medications for violent, agitated pts in withdrawal
antipsychotics
medication for violent patients with psychosis/mania
De-escalation first
Security if needed
Restraints only if necessary
1st step management of violent/agitated patients
no, always medical
is delirium a psychiatrivc illness?
more often medical/substance
do visual hallucinations indicate a medical or psych condition?
delirium
fluctuating mental status---->
Renally excreted → ↑ risk with dehydration, NSAIDs, ACE-Is, thiazides
increased risk of lithium toxicity in these conditions
-GI symptoms early, progresses to neuro and cardiac in severe cases
neuro symptoms: ataxia, slurred speech, hyperreflexia
cardiac: seizures, coma, DI
clinical progression of lithium toxicity
Stop lithium immediately
IV normal saline
Check lithium level (trend matters more than single value)
Hemodialysis if severe
management of lithium toxicity
Dopamine antagonism (antipsychotics)
Can occur any time, not just initiation
cause of neuroleptic malignant syndrome
hyperthermia, lead pipe muscle rigidity, AMS
what is the classic triad of neuroleptic malignant syndrome?
↑ CK, leukocytosis
lab findings associatedw tih neuroleptic malignant syndrome
days to weeks
typical onset of NMS
1. Stop antipsychotic
2. ICU-level supportive care
3. Cooling, IV fluids
3. Dantrolene (↓ muscle rigidity)
4. Bromocriptine or amantadine (dopamine agonists)
management of neuroleptic malignant syndrome
-dantrolene (decrease muscle rigidity)
-bromocriptine or amantadine (dopamine agonists)
pharm agents used in management of NMS
Antihistamines (1st gen)
TCAs
Antipsychotics
Antiparkinsonian meds
Plants (deadly nightshade)
causes of anticholinergic delirium
nightshade
plant that can cause anticholinergic delirium

"Hot as a hare, dry as a bone, blind as a bat, mad as a hatter"
-hyperthermia
-dry skin and mucosa
-mydriasis
-urinaray retention
-delirum, hallucination
classic toxidrome of anticholinergic delirium
DRY skin in anticholinergic delirium
DIAPHORESIS in serotonin syndrome
main distinguishing clinical sign of anticholinergic delirium vs serotonin syndrome
Stop offending agent
Cooling, IV fluids
Physostigmine (ONLY if severe and no contraindications)
management of anticholinergic delirium
Tyramine ingestion (aged cheese, wine)
Drug interactions (SSRIs, TCAs, sympathomimetics)
causes of MAO-I related hypertensive crisis
severe HA, HTN, palpitations, chest pain
symptoms of MAOI-HTN crisis
intracranial hemorrhage
most concerning risk in MAOI-related hypertensive crisis
Immediate BP control
Phentolamine (preferred)
Nitroprusside or nicardipine if needed
ICU monitoring
Stop MAOI
managment of MAOI related HTN crisis
Phenotolamine
preferred pharm agent in management of MAOI related hypertensive crisis
lithium toxicity until proven otherwise
ataxia + lithium
clonus
rapidly alternating involuntary contraction and relaxation of a muscle in response to sudden stretch
NMS has rigidity
serotonin syndrome: clonus
how do you differentiate NMS and serotonin syndrome clinically?
Hypoxia
Hypoglycemia
Electrolyte abnormalities
Infection (UTI, sepsis, meningitis)
Head trauma / intracranial bleed
Thyroid storm
medical differential diagnosis for violent/agitated patient
cocaine, methamphetamine
substance intoxications associated with violence/agitation
benzo withdrawal
substance withdrawal associated with violent/agitated behavior
1. verbal de-escalation
2. environmental control
3. meds
4. restraints last resort
stepwise approach to managing a violent patient
loss of reality testing with hallucinations, delusions, or disorganized thought/behavior.
define acute psychosis
auditory>visual
type of hallucination more associated with psychosis
Vitals, glucose
CMP, CBC
TSH
Urine toxicology
CT head if new onset, focal deficits, or trauma
initial workup for acute psychosis
Antipsychotics (first line)
Benzodiazepines if agitation
acute pharm management of acute psychosis
PTSD
Major depressive disorder
Anxiety disorders
Substance use disorders
Dissociation
Somatic symptom disorders
Suicidal ideation
common psychiatric sequelae of abuse
Physicians
Medical students/residents
Nurses
Social workers
mandatory reporters of abuse
1. danger to self
2. danger to others (ex: command hallucinations to harm others)
3. gravely disables (unable to provide basic needs)
4. need for intensive monitoring
core indications for psychiatric hospitalization
Acute psychosis
Severe mania
Major depression with psychotic features
Catatonia
examples of severe psychiatric symptoms
catatonia
a state of unresponsiveness to one's outside environment, usually including muscle rigidity, staring, and inability to communicate
-indicates need for psychiatric hospitalization
Lacks capacity AND
Imminent danger to self or others OR
Gravely disabled
indications for involuntary admission (emergency hold)
clinical capacity
the ability to understand the benefits and risks of proposed healthcare, to understand possible alternatives, and to make and communicate a healthcare decision.
Understands condition
Appreciates consequences
Can reason about options
Can communicate a choice
how to assess capacity
1. imminent danger to self
2. imminent danger to others
3. gravelly disables
core criteria for involuntary committment
24-72 hours
typical duration of a involuntary hold
civil comittment
Legal process extending involuntary hospitalization beyond the emergency hold.
Patient continues to meet criteria:
Danger to self or others
Gravely disabled
Due process protections:
Judicial review
Legal representation
Right to hearing
requirments to civil commitment (court ordered hospitalization)
Right to humane treatment
Right to refuse non-emergent medications (varies by state)
Right to legal counsel
Right to appeal commitment
Right to confidentiality
rights of the patient even in involuntary hold
delirium
An acute, fluctuating disturbance in attention and awareness, with an underlying medical cause.
Acute onset (hours-days)
Fluctuating course
Impaired attention
Altered level of consciousness
key characteristics of delirium
inattention
hallmark clinical feature of delirium
visual
hallucination type most associated with delirium
Agitation or lethargy
Sleep-wake cycle disruption
behavior associated with delirium
Tachycardia
Diaphoresis
Blood pressure lability
autonomic conditions associated with delirium
hypoactive delirium
-most missed, highest mortality
most missed form of delirium
mixed (hyper and hypoactive) delirium
most common subtype of delirium
psychosis
Clear consciousness, fixed delusions
delirium until proven otherwise
fluctuating attention=
Low-dose antipsychotics for severe agitation
Avoid benzodiazepines except for withdrawal
pharm management of delirium
up to 50%
prevalance of delirium in post op (hip fx) patients
60-80%
prevalence of delirium in ICU patients
alzheimer's disease
Most common neurocognitive disorder (~60-70%)
early episodic memory loss
later: depresion , apathy, irritability, delusions
psychosis occurs late
clinical course of alzheimer's
Memory → language → visuospatial → executive decline
clinical course of functional impairments in alzheimer's
-executive dysfunction early
-depression, emotional lability, stepwise decline
clinical features of vascular dementia
vascular dementia
Stepwise decline
Symptoms worsen after vascular events
Common in chronic alcohol use
substance-indcued neurocognitive disorders are most commonly seen in this patient population
executive dysfunction
difficulty planning, thinking abstractly, initiating and inhibiting actions
Wernicke encephalopathy (acute)
Korsakoff syndrome (chronic)
alcohol specific neurocognitive syndromes