Pattern Recognition Receptors

Which receptor does not phagocytose?

Toll-like receptors

Which receptor actually is important in signaling?

Toll-like receptors

mannose receptor: target pathogen

bacteria

mannose receptor: ligand

LPS, CPs, ManLam

complement receptor 3/4: target pathogen

Bacteria/Fungi

Complement receptor 3/4: Ligand

b: oligosaccharaides, proteins

F: beta glucans

Dectin-1 target pathogens

bacteria and fungi

Dectin-1 ligands

B; Mycobacterial ligand

F: beta glucans

Macrophage receptor with collagenous structure (MARCO) target pathogen

Bacteria

MARCO ligand

LPS, proteins

Scavenger Receptor A target pathogens

Bacteria

Scavenger Receptor A ligands

LPS, LTA, proteins, CpG DNA

Scavenger Receptor B CD36 target pathogen

Bacteria

Scavenger Receptor B CD36 ligand

Diacylated lipopeptide

Lipopolysaccharide receptor CD14 target pathogen

Bacteria

lipopolysaccharide receptor CD14 ligand

Peptidoglycan, LPS, LTA, mannuronic acid

Describe Toll-like recepotrs

Family of 10 receptors with variable specificity for a range of pathogens.