Immunoglobulins

how many types of immunoglobulins are there

5

What is the most common immuno

IgG

Where is IgG found

Blood lymph and CSF

What the classical pathway power IgG has

activation of the complement system

What does IgG do in pregnancy

Placental transfer around 3-4 months

What does IgG do for opsonization

The fc portion sticks out to identify phagocytes with receptors, and fab portion attaches to antigen

Why does IgG do aggultination

Clumping all the antigens together makes them easier to be detected

What are the Antibodies of IgG mediated by

They’re dependent on cell mediated cytotoxicity

What does IgG do with natural toxins and viruses

neutralize them by attaching to active site so it can’t attach to anything

What percent of serum proteins does IgG make

15%

What is the structure of IgM

Pentomere ( 5)

When is IgM produced

1st antibody produced after exposure

What does IgM do similarly to IgG

Agglutination

What does IgM not do

It doesn’t cross the placenta, and it’s weak against toxins and viruses

Is IgD secreted

NO

Where can you find IgD

on b-cells membrane

Do we know the full function of IgD

NOPE

What is the form of IgE

Monomer or Dimer

What is the half life of IgE

2 days unless it binds to a mast cell or basophil

what does IgM activate

Complement system

What doe IgE do

stimulate mast cells to release histamine granules

What is so important about IgA

It’s big in mucosal membranes ( repiratory tract, GI, genital tract)

What is the half life of IgA

5.5 days

What does IgA agglutinate

viruses

What is IgA mainly used for

HIV, Heliobacter pylori, strep

what are antibodies held together by

Disulfide bonds