Lecture 29 - Chemiosmosis + ATP Synthase

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7 Terms

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Chemiosmosis

as protons flow back across the membrane through ATP synthase, ATP is generated

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ATP synthase units

F0 Unit - protons enter through here and it begins to rotate, which causes central shaft to rotate

  • protons energize the shifting of the shaft due to kinetic energy of movement

Central Shaft - rotates and causes conformational change to occur in F1 unit

F1 Unit - ATP is produced here due to conformational changes

<p>F0 Unit - protons enter through here and it begins to rotate, which causes central shaft to rotate</p><ul><li><p>protons energize the shifting of the shaft due to kinetic energy of movement </p></li></ul><p>Central Shaft - rotates and causes conformational change to occur in F1 unit</p><p>F1 Unit - ATP is produced here due to conformational changes </p>
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3 States of F1 Subunit

Open - free, low affinity for ADP + Pi, no catalysis occurring

Loose - Low affinity for ADP + Pi, it binds and is preparing for catalytic activity

Tight - High affinity for ATP + Pi catalysis, ATP formed

<p>Open - free, low affinity for ADP + P<sub>i</sub>, no catalysis occurring</p><p>Loose - Low affinity for ADP + P<sub>i</sub>, it binds and is preparing for catalytic activity</p><p>Tight - High affinity for ATP + P<sub>i</sub> catalysis, ATP formed </p>
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How is the ATP formed

ADP is forced to accept the phosphate (tight)

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12 protons = 1 full rotation of central shaft

4 protons for each ATP

3 ATP formed in 1 full rotation

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Each site willl always be in one comformation

Only one will be in tight conformation at a time

  • making ATP

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H+ gradient across ATP-synthase containing membrane is sufficient for ATP synthesis by organelles

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