Wound healing
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FlashcardsWhat are the 4 stages of wound healing?
HIPR
Haemostasis
Inflammation
Proliferation
Remodelling
What is first stage of wound healing?
Haemostasis (immediate)
Goal: Stop bleeding
Temporary vascular permeability increased to allow neutrophils, platelets and proteins in wound
Cause vasoconstriction to limit blood loss
Platelets and cytokines form haematoma, fibrin mesh stabilizes the clot
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8 Terms
What are the 4 stages of wound healing?
HIPR
Haemostasis
Inflammation
Proliferation
Remodelling
What is first stage of wound healing?
Haemostasis (immediate)
Goal: Stop bleeding
Temporary vascular permeability increased to allow neutrophils, platelets and proteins in wound
Cause vasoconstriction to limit blood loss
Platelets and cytokines form haematoma, fibrin mesh stabilizes the clot
What is the second stage of wound healing?
Inflammation (hours - days)
Goal: Remove debris and prevent infection
Signs: Redness, swelling, heat, pain.
What is the 3rd stage of wound healing?
Proliferation (days-weeks)
Goal: Rebuild tissue.
Fibroblasts produce collagen and extracellular matrix.
Angiogenesis: new blood vessels form.
Granulation tissue fills the wound.
Re-epithelialization: new skin cells cover the wound.
Myofibroblasts begin wound contraction.
What is the 4th stage of wound healing?
Remodelling (weeks-months)
Goal: Strengthen and reorganize tissue.
Collagen synthesis slows after 3 weeks, remodelling
Scar tissue forms and matures
Tissue strength gradually increases but may not reach OG
What is primary intention healing? (IGM-FTS = i got many fun times soon)
Wound edges close together
e.g. scalpel incision
Easier clot and scab formation
Less inflammation
Less granulation tissue
Fewer myofibroblasts
Better function return, healing time, scarring
What is secondary intention healing? (IGM-FTS = i got many fun times soon)
Wound healing occurs from bottom up as sides are not opposed
More inflammation
Granulates from bottom up so epithelial cells proliferate later
Many myofibroblasts to contract wound
Worse function return, healing time, scarring
What are the 7 types of acute wounds? ALCIPBA
Avulsion
Laceration
Contusion
Incision
Puncture
Burn
Abrasion