Anti-cancer med

What time of agent is Cyclophosphamide?

alkylating agent

What is Cyclophosphamide?

can kill at any time during the cell cycle

What kind of compound is a Cisplatin?

a platinum compound

What is Cisplatin?

can kill at any time during the cell cycle, INCLUDING the resting phase

What kind of analog is Methotrexate?

a folic acid analog anti-metabolite

What is Methotrexate?

works in the synthesis phase by disrupting DNA

What type of analog is Fluorouracil?

a pyrimidine analog anti-metabolite

What is Fluorouracil?

works in the synthesis phase by killing dividing cells

What is Vincristine?

a mitotic inhibitor; kills during the mitosis phase

What is Tamoxifen?

blocks estrogen receptors; used for established breast cancer disease and for reducing occurrence in high-risk pts

What are the adverse effects of Tamoxifen?

can only use it for 5 years due to risk of endometrial cancer; hot flashes, fluid retention, vaginal discharge, menstrual irregularities, teratogenesis

What is Leuprolide (Leupron)?

inhibits gonadotropin release, suppressing ovarian and testicular steroidogenesis -> blocks creation of estrogen and testosterone

What are the adverse effects of Leuprolide (Leupron)?

generally well tolerated; hot flashes; testosterone loss may aggravate bone pain