L2 structural proteins and the oral environment

Two main categories of proteins

fibrous globular

Three characteristics of fibrous protein, and two examples

Long, structural, insoluble; collagen keratin

3 characteristics of globular proteins, three examples of functions, three examples of these proteins

Compact, soluble, functional; catalysis, transport, defense; SA, histatins, IGA

Individual keratin proteins associate to form__which serves as an__that__

intermediate filaments, protective surface layer, resist physical stress

Why do different tissues require different levels of protection?

degree of keratinization reflects functional demands placed on tissue

How does collagen achieve its strong structural role?

hierarchical organization from AA sequence to triple helix to collagen fiber

What amino acid is great for the triple helix in collagen because it is small

GLY

Triple helix of collagen often has the motif GLY – X – Y what is usually X and what is usually Y

pro; hyp

Triple helix of collagen is stabilized by

H bond

Triple helix's of collagen form__ which are the strengthened by__that increase the strength and stability

fibrils, cross links

Collagen function in each of the four locations: gingiva, periodontal ligament, Dentin, healing wounds

Structural integrity, tooth support, structural framework, tissue repair

Functional protein properties often depend on modifications occurring after__. this can affect_,_,_

translation; stability, localization activity

__Is a cofactor needed for the enzyme prolyl hydroxylase that helps form collagen

vit C

If there's a vitamin C deficiency, scurvy will occur, why does this happen?

prolyl H-ase doesn’t form which reduces 3x helix stability