Regulation of Transcription in Eukaryotes

Transcription is difficult or impossible in the

closed conformation of tightly packed chromatin.

Activator and repressor proteins influence

the ability of RNA polymerase to initiate transcription.

Regulation

________ is more intricate than prokaryotes.

Genes are almost always organized

individually.

DNA is associated with proteins to form

compact chromatin.

Access to the DNA is allowed in the

loosely packed open conformation.

Constitutive genes

________: unregulated and have essentially constant levels of expression (ie actin)

Chromatin packing affects

gene expression.

Necessary to produce different cell types in an organism

cell differentiation

Where eukaryotic gene regulation occurs

Transcriptional regulation is common

RNA processing

Translation

Post-translation