Oxidizing Agent & Halogen Containing Compounds

Hydrogen Peroxide
Potassium Permanganate
Benzoyl Peroxide

OXIDIZING AGENTS

Hydrogen Peroxide

OXIDIZING AGENTS
MOA: liberation of nascent oxygen in living tissues

Potassium Permanganate

OXIDIZING AGENTS
MOA: protein denaturation

Nascent

Liberates one Oxygen.
Free Radical causes tissue damage to the microbe.

Benzoyl Peroxide

OXIDIZING AGENTS
- White granular powder that is explosive in its pure form
- Formulated with 30% water to make it safer to handle
- Induces proliferation of epithelial cells; both keratolytic and keratogenic

Chlorine
Iodine
Povidone- Iodine

Halogen-Containing Compounds

Chlorine

Halogen-Containing Compounds
- Used in the disinfection of water supplies
- MOA: formation of hypochlorous acid when dissolved in water

Iodine

Halogen-Containing Compounds
- One of the most effective and useful germicides
- MOA: iodination of phenylalanyl and tyrosyl residues in and oxidation of sulfhydryl groups in proteins

Povidone- Iodine

Halogen-Containing Compounds
- Complex of iodine with the nonionic surfactant PVP (aka iodophor)
- Extremely water soluble and releases iodine very slowly
- Nontoxic, nonvolatile, and nonstaining form of iodine that is not irritating to the skin or to wounds
- Used as an aqueous solution for presurgical disinfection of the incision site, to treat infected wounds and damage to the skin, and against local bacterial and fungal infections.