Li HW - Basic Pharm Priciples

What is the primary structure of the protein?

A. The interactions between subunits of the protein complex.
B. The sequence of the amino acids (from N- to C-) of the protein.
C. Non-linear 3 dimensional structure of the protein.
D. Local folded structures that form within a polypeptide due to interactions between atoms of the backbone
(alpha-helix and beta-sheet for example)

B. The sequence of the amino acids (from N- to C-) of the protein

What is the tertiary structure of the protein?

A. The interactions between subunits of the protein complex.
B. The sequence of the amino acids (from N- to C-) of the protein.
C. Non-linear 3 dimensional structure of the protein.
D. Local folded structures that form within a polypeptide due to interactions between atoms of the backbone
(alpha-helix and beta-sheet for example).

C. Non-linear 3 dimensional structure of the protien

What disease is related with mutation on the hemoglobin?

A. Sickle cell anemia.

B. Haemophilia.

C. Leukemia.

D. Lymphoma

A. Sickle Cell anemia

Which type of RNA has recently been approved by FDA as a drug?

A. LncRNA

B. tRNA

C. rRNA

D. siRNA

D. siRNA

Which base could be found in RNA but not in DNA?

A. Cytosine

B. Thymine

C. Uracil

D. Guanine

C. Uracil

Tertiary structures of protein are stabilized by
A. Hydrogen bonding
B. Salt bridge
C. Disulfide bond
D. Hydrophobic interactions
E. All of the above

E. all of the above

7. Which description is NOT correct?
A. Disulfide bond is important to maintain the protein structure.
B. Disulfide bond can be formed through Cys and Met.
C. Disulfide bonds can be broken by adding a reducing agent such as beta mercaptoethanol.

B. Disulfide bond can be formed through Cys and Met

Prion diseases are caused by:

A. RNA viruses
B. DNA viruses
C. Bacterial infection
D. Misfolded protein that can transmit its misfoldedness to normal variants of the same protein

D. Misfolded protein that can transmit its misfoldedness to normal variants of the same protein

9. What are the major functions of protein post translational modification?
A. Cellular localization.
B. Protein degradation.
C. Transcriptional regulation.
D. All of the above.

D. All of the above

10. Which unit can be found in the promoter region of a gene?
A. TATA box
B. exon
C. intron

A. TATA box

11. Genetic mutations may lead to (4 points)
A. Loss of expression of proteins.
B. Loss of function of proteins.
C. Gain of function of proteins.
D. All of the above.

D. All of the above.

2. The three-dimensional structure of a protein is a direct consequence of its primary structure.

True

13. A part of protein sequence and structure that can evolve, function, and exist independently of the rest of the
protein chain.

True

14. One gene only encodes one product.

False

15. Denaturation of protein is always irreversible.

False