Pathology and Endoscopy of Polyps

Gastric Fundus Gland Polyp
→ disorder gastric body epithelium
→ cystic and distorted glandular arrangement
→ minimal inflammation
→ hyperplasia of muscularis mucosa

Gastric Hyperplastic Polyp
→ Elongated or cystic glands of the stomach
→ Inflamed lamina propria
→ Ulcerated epithelium
→ Intestinal metaplasia
→ Stromal fibromuscular hyperplasia

Gastric Adenomatous Polyp
1) dysplastic columnar epithelium cells
→ striated borders
→ elongated nuclei
→ clumping of chromatin
2) associated with intestinal metaplasia

Gastric Hamartomatous Polyp
→ smooth muscle proliferation will cause arborization which makes the polyp form a tree pattern as the polyp divides into lobules of glandular tissue

Hamartomatous Polyp of the Small Bowel
→ smooth muscle proliferation will cause arborization which makes the polyp form a tree pattern as the polyp divides into lobules of glandular tissue

Tubular Adenoma
→ elongated crypts with normal crypt architecture
→ increased number of glands but fewer goblet cells
→ hyperchromatic nuclei
→ nuclear atypia or loss of polarity

Tubulovillous Adenoma
→ mix between tubular and villous adenoma

Villous Adenoma
→ lack of tubular structures, all villous

Sessile Serrated Polyps
→ characteristic sawtooth pattern of the epithelium
→ dilated crypt bases that are laterally spreading
→ goblet cells at the bases increase mucus production

Hyperplastic Polyps
→ sawtooth pattern of the epithelium
→ normal cells that lack dysplasia

Gastric Fundus Polyp
→ small sized polyp found in the gastric body

Gastric Hyperplastic Polyp
→ multiple red polyps found together in the stomach

Gastric Adenomatous Polyp
→ solitary polyp in the stomach - neoplastic

Hamartomatous Polyp
→ lobular “arborization” polyp

Tubular Adenoma
→ look like the gyri of the brain

Sessile-Serrated Polyp
→ flat difficult to see with telangiectasis (spider-webbing)

Hyperplastic Polyp

Inflammatory Polyp

Colonic Hamartomatous Polyp
→ dilated crypts
→ inflamed lamina propria