Immunology Chapter 3: Antigens and Antibodies

True

T/F: IgM can have a monomeric form or pentameric form.

Antigens

____________ elicit an immune response

epitope(s)

specific chemical moiety on an antigen which binds to molecules having an antigen binding receptor

A: antigen

B: Fab region

C: Heavy chains

D: Light chains

E: Fc region

A:

B:

C:

D:

E:

c. the B cell epitope must have sequential amino acids

Which of the following are NOT characteristic properties of B Cell epitopes?

a. the B cell epitope determinant must be close to the surface of a protein or other antigen

b. antibody (Ab) binding site and epitope require complementary 3-D shapes

c. the B cell epitope must have sequential amino acids

d. a and b

e. a and c

f. all of the above

f. all of the above

Adjuvants enhance the immunogenicity of an antigen by

a. prolonging persistence of antigen

b. increasing cytokine production

c. increasing recognition of pattern recognition receptors (PRR) of innate immunity

d. a and b

e. a and c

f. all of the above

f. all of the above

Which of the following are characteristic properties of T cell epitopes?

a. T cell epitopes are only recognized as tri-molecular complexes

b. Antigen processing is required to generate peptides that interact with MHC proteins

c. T cell epitopes are often internal portions of the antigenic molecule

d. a and b

e. b and b

f. all of the above

IgA, IgD, IgE, IgG, IgM

List the 5 classes of antibody heavy chains with the letters Ig and an uppercase letter.

IgM; IgD

Naive cells produce __________ and __________ isotypes in response to antigenic stimulation

e. a and c

Which of the following contribute to the immunogenicity of an antigen?

a. Antigen must be foreign or recognized as non-self

b. Antigens must have quaternary protein structure

c. Antigens must be able to be processed and/or presented by antigen presenting cells

d. a and b

e. a and c

f. all of the above

1. Proteins

2. Carbohydrates

3. Lipids

4. Nucleic Acids

Place the Biological molecule in order of their greatest to least antigenicity