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name the major water compartments & the name for water in each of them
- chamber of heart & blood vessels (plasma)
- tissue spaces (tissue fluid)
- cells (intracellular fluid)
- lymph capillaries (lymph)
name 3 specialized body fluids & state the location of each
- cerebrospinal fluid (brain & spinal cord)
- synovial fluid (joints)
- aqueous humor (eyeball)
explain how water moves between compartments; name the processes
filtration & osmosis
describe the 3 sources of water for the body & the relative amounts of each
- ingestion of liquids (1600 mL per day)
- food we eat (700 mL per day)
- metabolic water produced by cell respiration (200 mL per day)
describe the pathways of water output
- urine
- sweat
- water vapor exhaled in air
- feces
which pathway of water output is most important
urine
what kinds of variations are possible in water output
water intake = water output
name the hormones that affect fluid volume & state the function of each
- ADH
Increases reabsorption of water by the kidney tubules
- Aldosterone
Increases reabsorption of Na+ ions by the kidney tubules
- ANP
Decreases reabsorption of Na+ ions by the kidneys
define electrolyte
chemicals that dissolve in water & dissociate into their positive & negative ions; most are the inorganic salts, acids, & bases found in all body fluids
define cation
positive ions (ex: Na+, K+, Ca+2, Mg+2, Fe+2, & H+)
define anion
negative ions (ex: Cl-, HCO3-, sulfate, phosphate, & protein anions)
define osmosis
diffusion of water through a selectively permeable membrane
define osmolarity
concentration of dissolved materials present in a fluid
name the major electrolytes in plasma & state their functions
- Sodium
Creates much of the osmotic pressure of ECF; most abundant cation in ECF
Essential for electrical activity of neurons & muscle cells
- Chloride
Most abundant anion in ECF; diffuses easily into & out of cells; helps regulate osmotic pressure
Part of HCl in gastric juice
- Protein anions
name the major electrolytes in tissue fluid & state their functions
- Sodium
Creates much of the osmotic pressure of ECF; most abundant cation in ECF
Essential for electrical activity of neurons & muscle cells
- Chloride
Most abundant anion in ECF; diffuses easily into & out of cells; helps regulate osmotic pressure
Part of HCl in gastric juice
name the major electrolytes in intracellular fluid & state their functions
- Potassium
Creates much of the osmotic pressure in ICF; most abundant cation in ICF
Essential for electrical activity of neurons & muscle cells
- Phosphate
Most (85%) is found in bones & teeth
Primarily an ICF anion
Part of DNA, RNA, ATP, phospholipids
Part of phosphate buffer system
Protein anions
explain how the bicarbonate buffer system will react to buffer a strong acid
Strong acid reacts with sodium bicarbonate to produce salt (NaCl) that has no effect on pH & weak acid that has little effect of pH
NaOH + H2CO3 🠮 H2O + NaHCO3
explain how the phosphate buffer system will react to buffer a strong acid
Strong acid reacts with sodium monohydrogen phosphate to produce a salt that has no effect on pH & a weak acid that has little effect on pH
HCl + Na2HPO4 🠮 NaCl + NaH2PO4
explain why an amino acid may act as either an acid or a base
- Amino acids can act as an acid because it can donate excess hydrogen ion from the fluid to counteract increasing alkalinity
- Amino acids can act as a base because it can pick up an excess hydrogen ion from the fluid to counteract increasing acidity
describe the respiratory compensation for metabolic acidosis
Increased respirations to exhale CO2
describe the respiratory compensation for metabolic alkalosis
Decreased respirations to retain CO2
if the body fluids are becoming too acidic: what ions will the kidneys excrete? what ions will the kidneys return to the blood?
- Kidneys remove H+ ions from blood
- Kidneys excrete H+ ions in urine
- Kidneys create new bicarbonate ions and return them to the blood
which of the pH regulatory mechanisms works most rapidly
buffer systems
which of the pH regulatory mechanisms works most slowly
renal
which of the pH regulatory mechanisms has the greatest capacity to buffer an ongoing pH change
renal
which of the pH regulatory mechanisms has the least capacity to buffer an ongoing pH change
buffer systems
describe the effects of acidosis
Depresses synaptic transmission in the CNS; result is confusion, coma, & death
describe the effects of alkalosis
Increases synaptic transmission in the CNS & PNS; result is irritability, muscle spasms, & convulsions
list the 4 functions of water
- transports substances to and from cells
- aids in heat regulation
- assists in H+ balance in the body
- a medium (solution) for enzymatic action of digestion
who are the individuals that are more affected by changes in fluid balance
infants & elderly
List the reasons why some individuals are more affected by changes in fluid balance
- infants & elderly dehydrate more quickly
- infants' kidneys reabsorb less fluid
- elderly have less ADH & diminished thirst
what are signs of dehydration
- thirst
- weakness
- dizziness
- postural hypotension
- decreased urine production
- concentrated urine
- dry, cracked lips
- dry mucous membranes
- thick saliva
- dry, scaly skin
- poor tissue turgor
- flat neck veins
- low BP
- weak, thready pulse
- elevated temperature
a decrease in osmolarity 🠮 blood is (?)
dilute
an increase in osmolarity 🠮 blood is (?)
concentrated
2 largest parts of body (in this chapter/section)
water & electrolytes
most important buffer system in cells
protein buffer system
cellular fluid 🠮 too alkaline = (?)
amino acids donate
cellular fluid 🠮 too acidic = (?)
amino acids pick up
charge of cations
+ positive
charge of anions
- negative
ADH decreases when ...
there's too much water in the body
true/false: diarrhea & vomiting can cause dehydration
true
most water is lost through (?)
urine
regulates the water in the body
hypothalamus
metabolic water is the result of (?)
cell respiration
in osmosis, fluids moves from ...
an area of low concentration of water to an area of high salt concentration
intracellular fluid makes up (?) of the body
2/3
extracellular fluid makes up (?) of the body
1/3
possible causes of metabolic acidosis
- kidney disease
- ketosis
- diarrhea
- vomiting
possible causes of metabolic alkalosis
- overingestion of bicarbonate medications
- gastric suctioning
possible causes of respiratory acidosis
decreased rate or efficiency of respiration:
- emphysema
- asthma
- pneumonia
- paralysis of respiratory muscles
possible causes of respiratory alkalosis
increased rate of respiration:
- anxiety
- high altitude
compensation for respiratory acidosis
kidneys excrete H+ ions & reabsorb Na+ ions & bicarbonate ions
compensation for respiratory alkalosis
kidneys retain H+ ions & excrete Na+ ions & bicarbonate ions
the bicarbonate buffer system is important in both (?) & (?)
blood & tissue fluid
the phosphate buffer system is important in (?)
the regulation of the pH of the blood by the kidneys
the protein buffer system is the most important one in (?)
the intracellular fluid
equation that represents the correct depiction of the bicarb-carbonic acid relationship
H+ + HCO3- ⮂ H2CO3 ⮂ CO2 + H2O
(hydrogen + bicarbonate ⮂ carbonic acid ⮂ carbon dioxide + water)
when there is an increased number of H+ in the bloodstream, an increased production of (?) occurs
CO2
when there is an increased production of CO2 occurring, total minute ventilation will (?)
increase
what is the normal range of arterial pH
7.35 - 7.45
pH must be maintained with a narrow limit because an alteration in pH can significantly alter (?)
enzyme function
what are the 2 body organs responsible for the expression "the physiological buffer system"
lungs & kidneys
renal regulation of pH is generally a bit (?) than respiratory regulation of pH
slower
HCO3- (bicarbonate) is reabsorbed in the proximal tubule indirectly as (?)
CO2
if the pH is 7.2, the situation at the kidney will be one of (?) secretion of H+
increased
a pH of 7.2 accompanying a [HCO3-] of 31 mEq/L would be an example of what type of acid-base disorder
respiratory acidosis
a pH of 7.6 accompanying a [HCO3-] of 31 mEq/L would be an example of what type of acid-base disorder
metabolic alkalosis
fluid found in tissue spaces between cells
tissue fluid
fluid found in blood vessels
plasma
fluid found in lymph vessels
lymph
location of cerebrospinal fluid
around & within the CNS
location of aqueous humor
within the eyeball
location of synovial fluid
within joint cavities
location of serous fluid
between membranes such as the pleural membranes
specialized cells in the hypothalamus that detect changes in the osmolarity of body fluids
osmoreceptors
when the body is dehydrated, the osmolarity of body fluids (?) because there is (?) dissolved material in proportion to water
increases; more
after drinking liquids during dehydration, as water is absorbed by the digestive tract, the osmolarity of the body fluids (?) or (?) toward normal
decreases; decreases
the hormone (?) is produced by the hypothalamus & stored in the (?) pituitary gland
ADH; posterior
function of ADH
increase reabsorption of water by the kidneys
what type of situation is ADH secreted
dehydration
in dehydration, ADH effects cause urinary output to (?)
decrease
the hormone aldosterone is produced by the (?) & (?) the reabsorption of (?) by the (?)
adrenal cortex; increases; sodium ions; kidney tubules
what are 2 types of situations that stimulate the secretion of aldosterone
- when Na+ ion concentration of blood decreases
- when there's a significant decrease in BP
if there is too much water in the body, the secretion of ADH will (?) & urinary output will
decrease; increase
if blood volume or BP increases, the heart will produce the hormone (?), which will (?) the excretion of sodium ions & water
ANP; increase
when electrolytes are in water, they dissociate into their (?)
positive & negative ions
most electrolytes are (?) molecules that includes (?), (?), & (?)
inorganic; salts, acids, & bases
electrolytes help create the (?) of body fluids & help regulate the (?) of water between water compartments
osmolarity; osmosis
water will move by osmosis to a compartment with a (?) concentration of electrolytes
greater
intracellular fluid:
- most abundant cation:
- most abundant anion:
- potassium
- phosphate & proteins
tissue fluid:
- most abundant cation:
- most abundant anion:
- protein anions:
- sodium
- chloride
- few
plasma:
- most abundant cation:
- most abundant anion:
- protein anions:
- sodium
- chloride
- many
aldosterone
increases the reabsorption of sodium by the kidneys; increases the excretion of potassium by the kidneys
calcitonin
increases the removal of calcium & phosphorus from the blood & into bones
parathyroid hormone
increases the reabsorption of calcium & phosphorus from the bones to the blood
ANP
increases the excretion of sodium by the kidneys
to compensate for a state of acidosis, the kidneys will excrete (?) ions & will conserve (?) ions & (?) ions
hydrogen; sodium; bicarbonate
to compensate for a state of alkalosis, the kidneys will excrete (?) ions & (?) ions & will conserve (?) ions
sodium; bicarbonate; hydrogen
how long does it take the kidneys to respond to pH change
a few hours to a few days