Respiratory Top 200 Drugs

Albuterol \[brand/generic\]

Proventil HFA, Proair HFA, Proair Respiclick, Ventolin HFA

Albuterol \[class\]

Selective beta-2 agonist

Albuterol \[indications\]

1. asthma (acute exacerbation)
2. asthma (bronchospasm)
3. exercise-induced asthma prevention
4. COPD (acute symptom relief)
5. COPD (acute exacerbation)

Albuterol \[MOA\]

Beta-2 agonist → increase cAMP → smooth muscle relaxation

Albuterol \[common AEs\]

Nausea

pharyngitis

rhinitis

throat irritation

upper RTIs

tremor

nervousness

Fluticasone (nasal) \[brand/generic\]

Flonase

Fluticasone (nasal) \[class\]

antiallergy agent (intranasal corticosteroid)

Fluticasone (nasal) \[indications\]

1. allergic rhinitis
2. nonallergic rhinitis
3. nasal polyps

Fluticasone (nasal/inhalation) \[MOA\]

inhibition of inflammatory mediators

Flonase (nasal) \[common AEs\]

Headache

nasal irritation and burning

Fluticasone (inhalation) \[brand/generic\]

Flovent

Fluticasone (inhalation) \[class\]

antiasthmatic (inhaled adrenal corticosteroid)

Fluticasone (inhaled) \[indication\]

Asthma

Fluticasone (inhalation) \[CIs\]

hypersensitivity to milk protein

acute or primary asthma treatment

Fluticasone (inhalation) \[common AEs\]

Pharyngeal candidiasis

Fluticasone/Salmeterol \[brand/generic\]

Advair Diskus/HFA

Fluticasone/Salmeterol \[class\]

antiasthmatic/COPD agent (ICS/LABA)

Fluticasone/Salmeterol \[indications\]

1. asthma
2. COPD

Fluticasone/Salmeterol \[CIs\]

Hypersensitivity to milk proteins

acute exacerbations of asthma or COPD

Fluticasone/Salmeterol \[BBW\]

increased asthma-related death

Fluticasone/Salmeterol \[Common AEs\]

HA

pharyngitis

upper RTI

difficulty speaking

Montelukast \[brand/generic\]

Singulair

Montelukast \[class\]

antiasthmatic/antiallergy (LTRA)

Montelukast \[indications\]

1. asthma
2. exercise-induced bronchoconstriction
3. seasonal allergic rhinitis

Montelukast \[BBW\]

Behavior and mood-related effects

Budesonide/Formoterol \[brand/generic\]

Symbicort

Budesonide/Formoterol \[class\]

Antiasthmatic/COPD agent (ICS/LABA)

Budesonide/Formoterol \[indications\]

1. asthma


1. COPD

Budesonide/Formoterol \[MOA\]

ICS/LABA

Budesonide/Formoterol \[BBW\]

Asthma related death

inc. risk of hospitalization in pediatrics

Budesonide/Formoterol \[common AEs\]

upper RTIs

Ipratropium/Albuterol \[brand/generic\]

Combivent Respimat, DuoNeb

Ipratropium/Albuterol \[class\]

COPD agent (SAMA/SABA)

Ipratropium/Albuterol \[indication\]

COPD

Ipratropium/Albuterol \[CIs\]

hypersensitivity to atropine

hypersensitivity to soya lecithin (soybean, peanut products)

Ipratropium/Albuterol \[common AEs\]

bronchitis

upper RTIs

Tiotropium \[brand/generic\]

Spiriva

Tiotropium \[class\]

COPD agent (anticholinergic bronchodilator)

Tiotropium \[indications\]

1. COPD
2. Asthma

Tiotropium \[MOA\]

competitive inhibition of muscarinic receptors

Tiotropium \[CIs\]

hypersensitivity to tiotropium, ipratropium, or milk protein

Tiotropium \[Common AEs\]

Xerostomia

upper RTI

Codeine w/ Guaifenesin \[brand/generic\]

Mytussin AC, Robitussin AC

Codeine w/ Guaifenesin \[class\]

Antitussive/expectorant

Codeine w/ Guaifenesin \[indications\]

1. cough

Codeine w/ Guaifenesin \[MOA\]

depression of medullary cough reflex

Codeine w/ Guaifenesin \[common AEs\]

N/V

constipation

somnolence

Codeine w/ Guaifenesin \[CIs\]

Chronic pulmonary disease or SOB

within 14 days of stopping MAOI

tonsillectomy or adenoidectomy

children

Codeine w/ Guaifenesin \[BBW\]

Codeine may be habit forming

Varenicline \[brand/generic\]

Chantix

Varenicline \[class\]

smoking cessation aid

Varenicline \[indication\]

smoking cessation

Varenicline \[MOA\]

binds neuronal nicotinic acetylcholine receptors

Varenicline \[common AEs\]

dream disorder

nausea

headache

insomnia

irritability