Respiratory Top 200 Drugs

Albuterol [brand/generic]

Albuterol [brand/generic]

Proventil HFA, Proair HFA, Proair Respiclick, Ventolin HFA

Albuterol [class]

Selective beta-2 agonist

Albuterol [indications]

1. asthma (acute exacerbation)

2. asthma (bronchospasm)

3. exercise-induced asthma prevention

4. COPD (acute symptom relief)

5. COPD (acute exacerbation)

Albuterol [MOA]

Beta-2 agonist → increase cAMP → smooth muscle relaxation

Albuterol [common AEs]

Nausea

pharyngitis

rhinitis

throat irritation

upper RTIs

tremor

nervousness

Fluticasone (nasal) [brand/generic]

Flonase

Fluticasone (nasal) [class]

antiallergy agent (intranasal corticosteroid)

Fluticasone (nasal) [indications]

1. allergic rhinitis

2. nonallergic rhinitis

3. nasal polyps

Fluticasone (nasal/inhalation) [MOA]

inhibition of inflammatory mediators

Flonase (nasal) [common AEs]

Headache

nasal irritation and burning

Fluticasone (inhalation) [brand/generic]

Flovent

Fluticasone (inhalation) [class]

antiasthmatic (inhaled adrenal corticosteroid)

Fluticasone (inhaled) [indication]

Asthma

Fluticasone (inhalation) [CIs]

hypersensitivity to milk protein

acute or primary asthma treatment

Fluticasone (inhalation) [common AEs]

Pharyngeal candidiasis

Fluticasone/Salmeterol [brand/generic]

Advair Diskus/HFA

Fluticasone/Salmeterol [class]

antiasthmatic/COPD agent (ICS/LABA)

Fluticasone/Salmeterol [indications]

1. asthma

2. COPD

Fluticasone/Salmeterol [CIs]

Hypersensitivity to milk proteins

acute exacerbations of asthma or COPD

Fluticasone/Salmeterol [BBW]

increased asthma-related death

Fluticasone/Salmeterol [Common AEs]

HA

pharyngitis

upper RTI

difficulty speaking

Montelukast [brand/generic]

Singulair

Montelukast [class]

antiasthmatic/antiallergy (LTRA)

Montelukast [indications]

1. asthma

2. exercise-induced bronchoconstriction

3. seasonal allergic rhinitis

Montelukast [BBW]

Behavior and mood-related effects

Budesonide/Formoterol [brand/generic]

Symbicort

Budesonide/Formoterol [class]

Antiasthmatic/COPD agent (ICS/LABA)

Budesonide/Formoterol [indications]

1. asthma

   1. COPD

Budesonide/Formoterol [MOA]

ICS/LABA

Budesonide/Formoterol [BBW]

Asthma related death

inc. risk of hospitalization in pediatrics

Budesonide/Formoterol [common AEs]

upper RTIs

Ipratropium/Albuterol [brand/generic]

Combivent Respimat, DuoNeb

Ipratropium/Albuterol [class]

COPD agent (SAMA/SABA)

Ipratropium/Albuterol [indication]

COPD

Ipratropium/Albuterol [CIs]

hypersensitivity to atropine

hypersensitivity to soya lecithin (soybean, peanut products)

Ipratropium/Albuterol [common AEs]

bronchitis

upper RTIs

Tiotropium [brand/generic]

Spiriva

Tiotropium [class]

COPD agent (anticholinergic bronchodilator)

Tiotropium [indications]

1. COPD

2. Asthma

Tiotropium [MOA]

competitive inhibition of muscarinic receptors

Tiotropium [CIs]

hypersensitivity to tiotropium, ipratropium, or milk protein

Tiotropium [Common AEs]

Xerostomia

upper RTI

Codeine w/ Guaifenesin [brand/generic]

Mytussin AC, Robitussin AC

Codeine w/ Guaifenesin [class]

Antitussive/expectorant

Codeine w/ Guaifenesin [indications]

1. cough

Codeine w/ Guaifenesin [MOA]

depression of medullary cough reflex

Codeine w/ Guaifenesin [common AEs]

N/V

constipation

somnolence

Codeine w/ Guaifenesin [CIs]

Chronic pulmonary disease or SOB

within 14 days of stopping MAOI

tonsillectomy or adenoidectomy

children <2 years

Codeine w/ Guaifenesin [BBW]

Codeine may be habit forming

Varenicline [brand/generic]

Chantix

Varenicline [class]

smoking cessation aid

Varenicline [indication]

smoking cessation

Varenicline [MOA]

binds neuronal nicotinic acetylcholine receptors

Varenicline [common AEs]

dream disorder

nausea

headache

insomnia

irritability