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2,3-bisphosphoglycerate (2,3-BPG)
chemical in red blood cells that affects hemoglobin's affinity for oxygen
abdominal aortic aneurysm
dilation of the abdominal aorta that generally occurs below the renal areries and above the bifurcation of the common iliac arteries
abduction
movement of a body part away from the midline
aberrant conduction
transmission of an electrical impulse through the heart's conductive system in an abnormal fashion
abortion
termination of pregnancy before the 20th week of gestation. The term refers to both miscarriage and induced abortion. Commonly used for elective termination of pregnancy rather than for a miscarriage or the loss of a fetus by natural means.
abrasion
scraping or abrading away of the superficial layers of the skin; an open soft tissue injury
abruptio placentae
separation of the placenta from the uterine wall
absence seizure
type of generalized seizure with sudden onset, characterized by a brief loss of awareness and rapid recovery
absolute refractory period
span of the cardiac cycle when stimulation produces no depolarization at all.
absolute zero
temperature at which all molecular motion stops (-273 C or -459 F)
acceleration
rate at which speed or velocity increases
acclimatization
reversible changes in body structure and function by which the body becomes adjusted to a change in environment
acid
substance that liberates hydrogen ions when in solution; substance that gives up a proton or protons during chemical reactions
acquired immunity
protection from infection or disease that is (1) developed by the body over time after exposure to an antigen (active acquired immunity) or (2) transferred to the person from an outside source such as from the mother through the placenta or as a serum (passive acquired immunity)
acrocyanosis
cyanosis of the extremities
action potential
stimulation of myocardial cells, as evidenced by a change in the membrane electrical charge, that subsequently spreads across the myocardium
activated charcoal
powder, usually premixed with water, that will adsorb (bind) some poisons and help prevent them from being absorbed by the body
active immunity
acquired immunity that occurs following exposure to an antigen and results in the production of antibodies specific for the antigen; protection against disease developed after birth as a result of a direct exposure FC to the disease.
active transport
movement of a substance through a cell membrane against the osmotic gradient; that is, from an area of lesser concentration to an area of greater concentration, opposite to the normal direction of diffusion. Requires the use of energy
acute arterial occlusion
sudden occlusion of arterial blood flow
acute coronary syndrome (ACS)
spectrum of coronary artery disease processes from myocardial ischemia and myocardial injury to myocardial infarction that includes the clinical entities of stable and unstable angina and acute myocardial infarction
acute gastroenteritis
sudden onset of inflammation of the stomach and intestines
acute kidney injury (AKI)
sudden onset of severely decreased urine production; also called acute renal failure (ARF)
acute myocardial infarction (AMI)
most serious stage of myocardial infarction (MI); irreversible injury (necrosis) of the myocardium. The term is sometimes used interchangeably with or as a synonym to MI
acute pulmonary embolism
blockage that occurs when a blood clot or other particle lodges in a pulmonary artery
acute respiratory distress syndrome (ARDS)
form of pulnonary edema caused by fluid accumulation in the interstitial space within the lungs, causing collapse of alveoli, which results in progressive hypoxemia
acute tubular necrosis
kidney injury caused by damage to the kidney tubule cells
addiction
compulsive and overwhelming dependence on a drug; may be physiologic dependence, psychological dependence, or both
Addison's disease
endocrine disorder characterized by adrenocortical insufficiency. Symptoms may include weakness, fatigue, weight loss, and hyperpigmentation of skin and mucous membranes
Addisonian crisis
form of shock associated with adrenocortical insufficiency and characterized by profound hypotension and electrolyte imbalances
adduction
movement of a body part toward rthe midline
adhesion
union of normally separate tissue surfaces by a fibrous band of new tissue
advance directive
legal document prepared when a person is alive, competent, and able to make informed decisions about health care. The document provides guidelines on treatment if the person is no longer capable of making decisions.
adverse childhood experiences (ACEs)
traumatic childhood incident or circumstance, such as a dysfunctional family, abuse by a parent or other, or neglect
adverse reaction
deleterious effect from a correclty dosed medication
affect
visible indicators of mood
afferent
carrying impulses toward the central nervous system (brain or spinal cord). sensory nerves for example.
afterbirth
placenta and accompanying membranes that are expelled from the uterus after the birth of a child
afterload
resistance within the blood vessels that a contraction of the heart must overcome to eject blood- the resistance against which the heart must pump. In cardiac p hysiology, defined as the tension of cardiac muscle during systole (contraction). Also called peripheral vascular resistance
ageism
discrimination against aged or elderly people
aggregate
to cluster or come together
airborne
transmitted through the air by droplets or particles
alkali
substance that liberates hydroxyl ions (OH-) when in solution; a strong base
allergen
substance capable of inducing an allergic reaction or specific hypersensitivity. Allergens may be protein or nonprotein, although most are proteins.
allergic reaction
exaggerated response by the immune system to a foreign substance
allergy
hypersensitive state acquired throgh exposure to a particular allergen
alpha radiation
low-level form of nuclear radiation; a weak source of energy that is stopped by clothing or the first layers of skin.
altered mental status (AMS)
changed level of mental funcgtion, short of unresponsiveness, which may manifest as confusion, amnesia, lack of alertness, disorientation, or other non-normal mental state.
antidote
substance that will neutralize a specific toxin or counteract its effect on the body
Alzheimer's disease
progressive, degenerative brain disorder, resulting in impaired memory, thinking, and behavior; thhe most common cause of dementia
amniotic fluid
clear, watery fluid that surrounds and protects a developing fetus
amniotic sac
membranes that surround and protect the developing fetus throughout the period of intrauterine development
ampere
basic unit for measuring the strength of an electric current
amphiarthroses
joints that permit very limited motion such as the joints between vertebrae and between the sacrum and ilium
amputation
severance, removal, or detachment, either partial or complete, of a body part
amyotrophic lateral sclerosis (ALS)
progressive degeneration of the motor neurons that control voluntary movement, resulting in weakness, loss of motor control, difficulty speaking, and cramping. Also called Lou Gehrig's disease
anabolism
constructive or "building up" phase of metabolism in which cells convert nonliving substances into living cytoplasm; the synthesis of steroid compounds by the boy which requires the use of energy; the opposite of catabolism
anaerobic
ability to live without oxygen
anaphylactic shock
form of shock in which histamine causes general vasodilation, precapillary sphincter dilation, capillary engorgement, and fluid movement into the insterstitial compartment
anaphylaxis
life-threatening allergic reaction
anastomosis
cross connection between two blood vessels or other tubular structures
anemia
inadequate number of red blood cells or inadequate hemoglobin within the red blood cells
aneurysm
dilation or ballooning in the wall of a blood vessel, usually an artery, caused by a congenital defect or weakness in the wall of the vessel.
anger
hostility or rage to compensate for an undelrying feeling of anxiety
angina pectoris
chest pain that results when the heart's oxygen requirements exceed oxygen supply available from blood
angioedema
localized swelling of deeper tissues and/or mucosa caused by fluid leaks from capillaries into interstitial spaces
angioneurotic edema
marked edema of the skin that usually involves the head, neck, face, and upper airway; a common manifestation of severe allergic reactions and anaphylaxis
ankylosing spondylitis
form of inflammatory arthritis that primarily affects the spine
anorexia nervosa
psychological eating disorder marked by excessive fasting or refusal to eat
anoxic hypoxemia
oxygen deficiency due to disordered pulmonary mechanisms of oxygenation
antepartum
before the onset of labor
anterior cord syndrome
condition caused by bony fragments or pressure compressing the arteries of the anterior spinal cord and resulting in loss of motor function and sensation to pain, light touch, and temperature below the injury site.
anterograde amnesia
inability to remember events that occurred after the trauma that caused the condition
antibody
substance produced by B lymphocytes in response to the presence of a foreign antigen that will combine with and control or destroy the antigen, thus preventing infection
anticoagulant
medication that inhibits blood clotting
antidiuresis
formation and passage of a concentrated urine, preserving blood volume
antigen
marker on the surface of a cell that identifies it as "self' or "non-self"; substance that is capable, under appropriate conditions, of inducing a specific immune response
antimuscarinic
drugs/medications that antagonize muscarinic cholinergic receptors, often for the purpose of relieving muscarinic poisoning symptoms such as gastrointestinal distress. Conversely, overuse of these can produce its own toxidrome, including altered mental status ranging from delirium to coma
anuria
no elimination of urine
anxiety
state of uneasiness, discomfort, apprehension, and restlessness
anxiety disorder
condition characterized by dominating apprehension and fear
aortic dissection
degeneration of the wall of the aorta
aortocaval compression
pressure on the aorta and vena cava by the gravis uterus in the supine pregnant patient
APGAR score
numerical system of rating the condition of a newborn. It evaluates the newborn's heart rate, respiratory rate, muscle tone, reflex irritability, and color
aphasia
absence or impairment of the ability to communicate through speaking, writing, or signing as a result of brain dysfunction; occurs when the individual suffers a brain injury due to stroke or head injury and no longer has the ability to speak or read. If it is "sensory" the patient cannot understand the spoken word. If it is "motor" the patient can understand what is said but cannot speak. If it is "global" the patient has both the sensory and motor effects.
apnea
absence of or a temporary stop in breathing
appendicitis
inflammation of the vermiform appendix at the juncture of the large and small intestines
aqueous humor
clear fluid filling the anterior chamber and surrounding the iris, pupil, and lens of the eye
arachnoid membrane
middle layer of the meninges
arrhythmia
any deviation from the normal electrical rhythm of the heart. Also called dysrhythmia
arterial gas embolism (AGE)
air bubble, or air embolism, that enters the circulatory system from a damaged lung
arteriole
small artery
arteriosclerosis
thickening, loss of elasticity, and hardening of the walls of the arteries from calcium deposits
arteriovenous malformation (AVM)
abnormal tangle of blood vessels that causes multiple irregular connections between arteries and veins
artery
vessel that carries blood from the heart to the body tissues
arthritis
inflammation and stiffness of the joints
articular surface
portion of a bone that directly contacts another bone within a joint
artifact
deflection on the ECG. produced by factors other than the heart's electrical activity
ascending loop of Henle
part of a kidney tubule leading from the descending loop of Henle to the distal convoluted tubule
ascending reticular activating system
series of nervous tissues that keep the human system in a state of consciousness