ACE Inhibitors -pril

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Last updated 9:19 AM on 8/30/26
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5 Terms

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Drugs in class

captopril (Capoten)

lisinopril (Prinivil)

enalapril (Vasotec)

ramipril (Altace)

trandolapril (Mavik)

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Properties/MOA

·       Blocks A1 conversion to A2

·       ↓ A2 therefore ↓ aldosterone

·       ↓ afterload, ↓ preload

·       ↓ mortality rate (↑ lifespan)

Accumulates bradykinins

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Effects/Adverse Rxn

·       Vasodilates (No A2)

·       First dose hypotension (reduces BV)

·       Dry persistent cough (due to ↑ bradykinins)

·       Hyperkalemia

·       Neutropenia

·       Angioedema

·       Fetal harm

Renal artery stenosis

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Contraindications

Contraindicated w/renal artery stenosis or mothers wanting to get pregnant

Interactions w/diuretics, antihypertensives, lithium, NSAIDS

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Nursing Info.

·       Check K and BP

·       Do not give if systolic BP <100

·       Used in HTN, HF, post MI, Diabetic Nephropathy, CVA (stroke)

·       Only ONE can be given IV (enalapril)

All can be taken w/food EXCEPT captopril & moexipril