Pediatric Pharmacokinetics: Case Examples and Dosage Calculations

These flashcards cover critical vocabulary from the lecture on pediatric pharmacokinetics, including definitions of terms related to drug dosage calculations and pharmacokinetic principles.

Pediatric Pharmacokinetics

The study of how drugs are absorbed, distributed, metabolized, and excreted in children.

Allometric Scaling

A method used to predict pharmacokinetic parameters based on body weight and other biological factors.

AUC (Area Under the Curve)

A pharmacokinetic measurement that represents the total drug exposure over time.

CL (Clearance)

The volume of blood or plasma that is completely cleared of a drug per unit time.

PK Parameters

Key statistical values that describe the behavior of a drug in the body, including clearance (CL), volume of distribution (Vd), and half-life.

Dose Adjustment

Modifying the amount of drug administered based on the patient's response or characteristics.

Population PK Methods

Statistical approaches used to analyze pharmacokinetics across a population to optimize dosing regimens.

Goal Cpss (Steady-State Concentration)

The desired concentration of a drug in the bloodstream that is achieved after administering medication for a certain period.

FDA Dosing Recommendations

Guidelines established by the Food and Drug Administration for drug dosing based on clinical studies and demographic data.

Joint Commission Standards

National patient safety standards that guide healthcare organizations in providing safe and effective care.

Extrapolation from Adult Data

Applying pharmacokinetic information obtained in adults to pediatric patients due to limited studies in the latter.

Loading Dose

A higher initial dose of a drug given to rapidly achieve therapeutic concentration.

Maintenance Dose

The dose of a drug administered to maintain drug concentrations within the therapeutic range.