Negative selection in germinal centers

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How can a mutated immunoglobulin affect the B cell in the germinal center?

A mutated immunoglobulin can change the affinity of the immunoglobulin to recognize self-antigen.

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Why is negative selection needed in the germinal center?

To ensure that self-reactivity does not occur.

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What happens to self-reactive B cells within the germinal center?

Self-reactive B cells that significantly interact with TH cells must be removed or rendered inactive to prevent autoimmune disease.

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