Key Drugs Guy

TDM: carbamazepine

4-12 mcg/mL

TDM: digoxin

af: 0.8-2 ng/mL
hf: 0.5-.08 ng/mL

TDM: getamicin

peak: 5-10 mcg/mL
trough: <2 mcg/mL

TDM: lithium

0.6-1.2 mEq/L

TDM: phenytoin/fosphenytoin

10-20 mcg/mL
free phenytoin: 102 mcg/mL

TDM: procainamide

4-10 mcg/mL
NAPA: 12-25 mcg/mL
combined: 10-30 mcg/mL

TDM: theophyllin

5-15 mcg/mL

TDM: tobramycin

peak: 5-10 mcg/mL
trough < 2 mcg/mL

TDM: valproic acid

50-100 mcg/mL

TDM: vancomycin

AUC/MIC: 400-600
trough: 10-15 mcg/dL
trough serious infection: 15-20 mcg/dL

TDM: warfarin

INR 2-3
2.5-3.5 in some cases

drugs that require non-PVC containers

HINT:
Leaches
Absorbs
To
Take
In
Nutrients

Lorazepam
Amiodarone
Tacrolimus
Taxanes (except paclitaxel)
Insulin
Nitroglycerin

drugs to mix in dextrose only

HINT
Only
Sugar
Only

Oxaliplatin
Sulfamethoxazole/trimethoprim
Amphotericin B

Drugs to mix in saline only

HINT
A
Dumb
Idiot
Amphibian
Can’t
Eat
Pie



Ampicillin
Daptomycin
Infliximab
Ampicillin/sulbactam
Caspofungin
Ertapenem
Phenytoin

Drugs requiring a filter

HINT
GAL Is PAT MaP



Golimumab
Amphotericin B (lipid containing)
Lipids
Isavuconazonium
Phenytoin (CIV)
Amiodarone
Taxanes
Mannitol > 20%
Parenteral nitrition

Do NOT refrigerate

HINT
Dear
Sweet
Pharmacist
Freezing
Makes
Me
Edgy



Dexmedetomidine
SMX-TMP
Phenytoin
Furosemide
Metronidazole
Moxifloxacin
Enoxaparin

Require Light protection

HINT
Protect
Every
Necessary
Med
from
Daylight





Phytonadine (VitK)
Epoprostenol
Nitroprusside
Micafungin
Doxycycline

HD drugs on NIOSH

antineoplastics
5-alpha-reductase inhibiter: finasteride, dutasteride
abortificants: mifepristone, misoprostol
anticoagulants: warfarin
antivirals: cidofovir, ganciclovir, valganciclovir
antiseizures: carbamazepine, oxcarbazepine, (fos)phenytoin, topiarmate, valproic aicd
BZDs: clonazepam, temazepam
diabetes: exanatide
dyslipidemia: lomitapide
heart failure: sprinoloctone
hepatitis: ribavirin
PAH: ambrosentan, bosentan, caitentan, riociguat
retinoic acid: tretinoin
SSRI: paroxetine
thiomides: methimazole, propylthiouracil
trasplant: cyclosporin, mcyphenolate, tacrolimus, sirolimus
autoimmune: acitretin, azathipurine, fingolimod, leflunomide, teriflunomide
hormonal: andrgoens, estrogens, oxytoncin, progestin, SERD/SERM, ulipristal

Drugs that can cause nephrotoxicity

aminoglycosides
amphotericin B
cisplatin
cyclosporine
loop diuretics
NSAIDs
polymyxin
radiographic constrast dye
tacrolimus
vancomycin

Drugs that increase K+ levels

canagliflozin
CNI
drospirenone
anything with K+
RAAS inhibitors
SMX-TMP

Drugs with BBW for liver damage

acetaminophen
amiodarone
bosentan
isoniazid
ketoconazole
leflunomide/teriflunomide
MTX
nefazodone
nevirapine
PTU
valproic acid

drugs hat require internal increase or dose decrease in CKD

amioglycosides
B-lactams (except antistaph and ceftriaxone)
fluconazole
NRTIs
Quinolones (except moxifloxacin)
vancomycin
anticoagulants
antiarrhythmics
H2RAs
metoclopramide
bisphosphonates
lithium
PDE-5 inhibitors

Drugs CI in CKD CrCl < 60

nitrfurantoin

Drugs CI in CKD CrCl < 50

tenofovir DF
voriconazole

Drugs CI in CKD CrCl < 30

Tenofovori AF
NSAIDs
Dabigatran
K+ sparing diuretics

Drugs CI in CKD eGFR < 30

metformin

Drugs CI in CKD others

meperidine
rivaroxaban
SGTL2 inhibitors

common live vaccines

MMR
intranasal Flu
cholera
rotavirus
oral typhoid
varicella
yellow fever

travel vaccines

Hep A,B
Japanese encephalitis
Meningococcus
polio
typhoid-IM
Choldera - PO
Typhoid - PO
yellow fever - SC

Abx that do NOT require a renal adjustment

antistaph penicillins
azithromycin, erythromycin
ceftriaxone
clindamycin
doxycycline
metronidazole
Moxifloxacin
Linezolid

drugs that increase both LDL and TG

loop. thiazides
efavirenz
atypical antipsychotics
immunosuppressants

drugs that increase LDL

fibrates
fish oil

drugs that increase TG

IV lipid emulsions
bile acid sequestrants

drugs that can increase BP

ADHD drugs
decongestatn
recreational substances
antidepressants
NSAIDs
Immunosuppressants
systemic steroid
EPOs
OC
VEGF inhibitors

IV meds for HTN emergency

Clevidipine
enalaprilate
esmolol
hydralazine
labetalol
nicardipine
NTG
nitroprusside

Drugs that worsen or cause HF

HINT: Drug Information NATION





DPP-4 inhibitors
Immunosuppressants
Non-DHPs
Antiarrhythmics
Thiazolidindiones
Itraconazole
Oncology drugs
NSAIDs

Drugs that can increase or prologn QT interval

antiarrhythmics class 1a 1c 3
antimalarials
azoles
macrolides
quinolones
lefamulin
SSRIs
TCAs
Mirtazipine, trazodone, venlafaxine
5-HT3 recepotr antagonists
droperidol, metoclopramide, promethazine
Androgen depriavation therapy
TKIs
Arsenic trioxide
cilostazol, donepezil, fingolimod, hydroxyzine, loperamide, methadone, ranolazine, solifenacin

drugs that cause immune mediate hemolytic anemia

penicilline
cephalosporins
isoniazid
levodopa
methyldopa
rifampin
quinidine
quinine
sulfonamides

drugs that cause G6PD deficiency hemolytic anemia

dapsone
methylene blue
nitrofurantoin
peglitociase
rasburicase
primaquine
quinidine
sulfonamides

immunization in sickle cell disease

Hib, PCVS15 or PCV20
for aslepnia: Men ACWY + boosters, Med B, pneumococcal

drugs that increase IOP

anticholinergics
decongestants
chronic steroids, eye drops
topiramate

drugs that cause PAH

cocaine
fenfluramine
methamohetamine
SSRI during pregnancy
weight loss drugs

drugs that cause pulmonary fibrosis

amiodarone, dronedarone
bleomycin
busulfan
carmustine

drugs that increase BG

thaizide
loops diuretics
cyclosporine
tacrolimuc
PIs
Quinolones
Antipsychotics
statins
steroids
cough syrup
niacin

drugs that decrease BG

B-blockers
Quinolones
Tramadol

drugs that can cause hypothyroidism

HINT: ITALC



Interferons
TKIs
Amiodarone
Lithium
Carbamazepine