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Major Neurocognitive Disorder
Significant cognitive decline in one or more domains interfering with independence.
Minor Neurocognitive Disorder
Modest decline, does not interfere with capacity for independence.
Dementia
An umbrella term that can fall under both major and minor neurocognitive disorders.
Delirium
Acute, fluctuating disturbance in attention and awareness, often due to medical condition.
CAM
Confusion Assessment Method, a useful tool in diagnosing delirium.
MMSE
Mini-Mental State Examination, a useful tool in diagnosing delirium.
Depression
Rapid onset, fluctuates, patient aware and distressed by memory loss.
Vascular Dementia
Stepwise decline.
Alzheimer's Dementia
Memory loss is early sign.
Lewy Body Dementia
Visual hallucinations, Parkinsonism.
Frontotemporal Dementia
Personality and behavioral changes.
HIV Dementia
Cognitive, motor, and behavioral impairments in advanced HIV.
AD-8
A screening tool for cognitive impairment, particularly Alzheimer's disease.
First sign of Alzheimer's Dementia
Memory loss, especially short-term (recent) memory.
Signs of Alzheimer's Dementia
Gradual memory loss, disorientation, word-finding difficulty, personality changes.
Lewy Body Dementia characteristics
Fluctuating cognition, visual hallucinations, parkinsonism, sensitivity to antipsychotics.
Frontotemporal Dementia characteristics
Early changes in behavior, personality, or language with relatively preserved memory.
Signs of Frontotemporal Dementia
Disinhibition, apathy, compulsive behavior, loss of empathy, poor insight.
Former name for Frontotemporal dementia
Pick's disease.
Treatment of Vascular Dementia
Treat underlying vascular risk factors (HTN, DM, cholesterol).
Goal in management of vascular dementia
Prevent further strokes and slow progression.
Amnestic disorder
Impairment in memory with preserved other cognitive functions, not due to delirium or dementia.
Primary cause of amnesia
Most common: Psychological trauma.
Other causes of amnesia
TBI, stroke, infections, substance use, Wernicke-Korsakoff syndrome.
Vitamin for preventing amnesia in alcoholism
Thiamine (Vitamin B1) - prevents Wernicke-Korsakoff syndrome.
Confabulation
Fabricated or misinterpreted memories without intent to deceive, often seen in amnesia.
Dissociative Amnesia
Inability to recall important autobiographical info, often traumatic; may be localized, selective, or generalized.
Dissociative Fugue
Subtype of amnesia; person travels and may *******************.
Dissociative Identity Disorder
2+ distinct personality states, memory gaps, trauma-related, often in women.
Depersonalization/Derealization Disorder
Persistent feelings of unreality or detachment; intact reality testing.
Difference between depersonalization and derealization
Depersonalization: Unreality or detachment from oneself; Derealization: Unreality or detachment from surroundings.
Difference between dissociative amnesia, fugue, and identity disorder
Amnesia: Inability to recall personal info.
Amnesia
Inability to recall personal info.
Fugue
Amnesia + travel and possible new identity.
DID
2+ identities, with amnesia between states.
Autobiographical Memory
Combines episodic + semantic memory of personal life events.
Semantic Memory
Facts and concepts (e.g., vocabulary, world knowledge).
Episodic Memory
Events in specific time and context (e.g., birthday party).
Procedural Memory
Skills and tasks (e.g., riding a bike).
Generalized Amnesia
Loss of entire life history.
Amnesia/Dissociation
Psychological, usually stress-related, no structural brain damage.
Schizophrenia
>6 months, 2+ symptoms (delusions, hallucinations, disorganized speech, negative symptoms).
Schizophreniform
Same as schizophrenia but 1-6 months.
Brief Psychotic Disorder
<1 month, full return to baseline.
Delusional Disorder
1+ non-bizarre delusion >1 month, no other psychosis.
Schizoaffective Disorder
Schizophrenia + mood disorder; psychosis present 2+ weeks without mood sx.
Positive Symptoms
Hallucinations, delusions, disorganized speech, bizarre behavior.
Negative Symptoms
Flat affect, alogia, avolition, anhedonia, asociality.
Atypical antipsychotics
1st line for Schizophrenia: Risperidone, Olanzapine, Aripiprazole.
Typical antipsychotics
2nd line: Typical antipsychotics like Haloperidol.
Clozapine
Not first line due to risk of agranulocytosis and serious side effects.
Better prognosis in Schizophrenia
Female, older onset, mood sx, good social support.
Worse prognosis in Schizophrenia
Male, early onset, negative symptoms, poor premorbid function.
Substance/Medication-Induced Psychotic Disorder
Diagnosis if someone only has psychosis while on a substance.
Brief Psychotic Disorder Specifiers
With marked stressor, without marked stressor, with postpartum onset.
Ideas of Reference
Believing events refer to oneself.
Alogia
Poverty of speech.
Tangentiality
Going off-topic.
Loss of ego boundaries
Inability to differentiate self from others.
Echolalia
Repeating others' words.
Affect
Observable emotion.
Mood
Sustained internal feeling.
Psychosis
Loss of contact with reality.
Hallucinations
Sensory experiences without stimuli.
Delusions
Fixed false beliefs.
Loose associations
Illogical shifting of ideas.
Word salad
Disorganized speech.
Thought blocking
Sudden stop in thought.
Loss of abstraction
Concrete thinking.
Magical thinking
Belief that thoughts can cause events.
PTSD
After trauma; intrusive thoughts, hypervigilance, avoidance, >1 month.
Acute Stress Disorder
Similar to PTSD, lasts 3 days-1 month.
Acute reaction to stress
Immediate, short-term reaction, often resolves on its own.
Adjustment Disorder
Emotional/behavioral sx in response to identifiable stressor within 3 months, not meeting criteria for another disorder.
Adjustment Disorder Specifiers
With depressed mood, anxiety, mixed anxiety and depressed mood, disturbance of conduct, mixed disturbance of emotions and conduct, unspecified.
Groups more likely to develop PTSD
Women, especially with prior trauma history; individuals with lack of social support, ongoing stress, or concurrent mental illness.