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Observational Studies
a statistical study is observational when it is conducted using PRE-EXISTING data and or collected without any exact design
ex: using data from product registrations and warranty cards
observing consumer purchases in a store
Retrospective
studies an outcome in the present by examining historical records
retro= back then
Prospective
identifies subjects in advance and collects data as events unfold
collects as it goes
Elements of a design:
experiment, factors, treatment, response variable
Factors
the variables being manipulated by setting them to particular values called levels (labels)
Treatment
the combination of factor levels assigned to a subject
Principles of design
Control
Random assignment
Replication
Blocking
Control
one can control the sources of variation other than the factors being manipulated by making conditions as similar as possible for all treatment groups
Control Treatment
special treatment class designed to mark the baseline of stud y
Random assignment
no single group is represented more heavily than another
Replication
Repeated observations at each treatment is called replicates. If the number of replicates is the same for each treamtment combo, the experiment is said to be balanced
1 factor, completely randomized design
2nd kind of replication
repeat entire experiment for a different group of subjects, under different circumstances or at different times
Blocking
Group or block subjects together according to some factor that is uncontrollable but may affect the response
ex: sex, ethnicity, marital status
in a grid, treatment will be at the top (horizontal) and block will be on the side (vertical)
Volume
Information increased by: selecting factors, choosing treatments, determining sample size
RANDOM ASSIGNMENT REDUCES..
NOISE
Noise
ERROR reduced by: randomly assigning treatments to the experimental units
BLINDING KEEPS OUT..
bias
2 sources of unwanted bias
those who might influence the results (subjects, treatment admins, technicians)
Those who evaluate the results (judges, experimenters, stakeholder)
Single-Blind Experiment
either the subjects OR the analysts are blinded
Double-Blind Experiment
both groups are blinded
best- keeps bias out
Confounding is good or bad?
BAD
Confounded definition
when the levels of one fact are associated with the levels of another factor
& is..
bad. means tow things are confounded
Lurking Variables is good or bad
BAD
Lurking Variables
“drives” two other variables in such a way that a causal relationship is suggested between the two
ex: the economy may be a lurking variable in business experiments
ANOVA can be applied to observational data IF
The box plots show equal spreads and symmetric, outlier-free distributions
Cons of ANOVA on Observational Data
Observational studies are frequently unbalanced
Randomization is usually absent
There is no control over lurking variables or confounding
Cannot draw causal conclusions even when the F-stat is significant
3 Different types of designs
Completely Randomized
Randomized Block
Factorial Design
Completely Randomized-
when each of the possible treatments is assigned to at least one subject at random
aka: one factor ANOVA
one factor with replication
Randomized Block-
two factors, but the experiment is not replicated
Factorial Design
has two factors with replication
Hypothesis for ANOVA
Ho: us=uw=unp
Ha: at least two means differ
Levels not connected by the same letter are
significantly different
Randomized Block
require randomizing the subject treatment within each block
Randomized Block has how many hypothesis
2
Factorial Designs
contains treatments that represent all possible combos of factors at different levels
2 factors with replication
1st step in factorial design
Test for Interaction first- the effect of changing the level of one factor depends upon the level of other factor
look for interacted term in effect tests and look at f test
Pitfalls in ANOVA
Watch out for changing variances
Be wary of drawing causality conclusions from observational studies
Be sure to fit an interaction term when it exists. If the interaction term is not significant, fit a simpler block design to test the main effects instead