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Flashcards of key vocabulary terms and definitions from the Papillomaviruses lecture.
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Human Papillomavirus (HPV)
More than 200 strains. Cause common warts, verrucas, or genital warts. High-risk strains are associated with specific types of cancer.
Virion structure
dsDNA, Baltimore Group 1; Icosahedral (T=7), non-enveloped; 60 nm diameter, composed of 72 pentamers; 360 copies of major capsid protein L1; 76 copies of minor capsid protein L2.
E1
Origin binding helicase.
E2
DNA binding protein; E1 helicase loader; tethers viral genomes to host chromosomes; transcriptional regulator.
L1
Major capsid protein, 360 per virion.
L2
Minor capsid protein, escorts genome through the endocytic pathways into the nucleus; packages the viral DNA in the capsid.
E6
Immune evasion; degrades p53 and PDZ binding proteins; upregulates telomerase.
E7
Immune evasion; degrades pRb family members; epigenetic modulator.
E5
Only encoded by alpha-HPVs; promotes cell growth; immune evasion.
Integration of HPV genome
On rare occasions the HR-HPV genome may randomly insert into the host chromosome. Only part of genome is inserted – if it contains E6/E7 coding region in absence of E2 this can lead to neoplasia.
Cervical disease: pathology
Cervical cancer is preceded by cervical disease, which has 3 stages termed ‘cervical intraepithelial neoplasia’ (CIN) or squamous intraepithelial lesion (SIN).
Transmission of HPV
HPV is primarily transmitted through direct skin-to-skin contact, often during sexual intercourse.
HPV vaccine
There are vaccines available that protect against certain high-risk and low-risk strains of HPV, significantly reducing the risk of cervical cancer.
CIN stages
Cervical intraepithelial neoplasia (CIN) is categorized into three stages: CIN 1 (mild dysplasia), CIN 2 (moderate dysplasia), and CIN 3 (severe dysplasia or carcinoma in situ).
HPV-related cancers
In addition to cervical cancer, HPV is associated with cancers of the oropharynx, anus, vulva, vagina, and penis.
Role of E2 in HPV
E2 protein plays a crucial role in regulating the transcription of viral genes and ensuring proper viral replication