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chemistry and structures
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Donepezil
Tx Alzheimer’s
Galantamine
Tx Alzheimer’s
binds allosterically at nicotine receptors and increases effects of ACh
Physostigmine
reversible carbamate
Neostigmine
no CNS penetration
Tx myesthenia gravis
Pyridostigmine
Permanantly charged methylpyridinium ion
Rivastigmine
Tx Alzheimer’s
Echothiophate
organophosphorus
ophthalmic solution used in Tx glaucoma
Tabun
nerve gas
Sarin
nerve gas
GF
nerve gas
Soman
nerve gas
VX
nerve gas
2-PAM
nerve gas antidote
Malathion
insecticide
organothiophosphate
selective toxicity
Chlorpyrifos
insecticide