General Pathology Lecture 12: Hypersensitivity Type III

What are the three antibodies that can cause Type III Hypersensitivity?

1. IgM

2. IgA

3. IgG

What do antibodies bind to in Type III Hypersensitivity?

Circulating antigens

What is formed in Type III Hypersensitivity?

Immune complex

iWhat can the immune complex be implanted into?

Tissue basement membranes

What does the immune complex activate?

Complement system

What is caused by the immune complex activating phagocytes?

Tissue damage

What is Phase 1 in Type III Hypersensitivity?

Immune complex formation

How long does it take for immune complex to form?

Within a week

What is Phase 2 in Type III Hypersensitivity?

Immune complex deposition

What are the three sites of Immune complex deposition?

1. Kidney

2. Joint

3. Endothelium

What is activated in Phase 2 of Type III Hypersensitivity?

Neutrophils/monocytes

What is Phase 3 in Type III Hypersensitivity?

Inflammation and tissue injury

What are the two results of Phase 3 of Type III Hypersensitivity?

1. Acute inflammation

2. Tissue injury

What is the Type III Hypersensitivity disease caused by medication injection?

Arthus reaction

What can Arthus reaction lead to?

Local tissue necrosis

What is the Type III Hypersensitivity disease caused by foreign protein injection?

Serum sickness

What can Serum sickness lead to?

Generalized reaction