Ch 5.2 Antigens

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48 Terms

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What is an antigen?

A unique molecule or part of a molecule that elicits an immune response.

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Where are antigens found?

On pathogens

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What distinguishes 'self' from 'non-self'?

Protein markers (antigens) on cell surfaces.

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What are MHC markers?

Self-antigens used by the immune system to recognise own cells.

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What are MHC markers also called?

Human Leukocyte Antigens (HLA).

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Where is MHC-I found?

On all nucleated body cells.

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What does MHC-I do?

Allows cytotoxic T cells or NK cells to identify cells as 'self'.

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Where is MHC-II found?

On antigen-presenting cells (APCs) like dendritic cells

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What does MHC-II do?

Helps activate the adaptive immune response.

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What are antibodies?

Proteins produced by B lymphocytes in response to antigens.

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Where are antibodies found?

Bound to B cells or secreted into the blood/lymph.

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What are antigens made of?

Usually proteins

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What determines blood types?

The antigens on the surface of red blood cells.

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How are antigens detected?

By receptors on B and T lymphocytes.

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What is an immunogen?

An antigen that triggers an immune response.

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What is an allergen?

An antigen that triggers an allergic response.

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What is a disease?

A condition that disrupts normal functioning of an organism.

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What is an infectious disease?

A disease caused by a pathogen.

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What is a non-infectious disease?

A disease caused by genetics

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What is a pathogen?

A microorganism or agent that causes disease.

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What are obligate pathogens?

Pathogens that always cause disease.

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What are opportunistic pathogens?

Pathogens that cause disease only when immunity is weakened.

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What are cellular pathogens?

Living pathogens like bacteria

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What are non-cellular pathogens?

Non-living agents like viruses

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How do bacteria reproduce?

By binary fission.

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How do bacteria cause disease?

By releasing toxins

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What is a bacterial carrier?

An infected person with no symptoms.

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What are protozoans?

Unicellular eukaryotic pathogens.

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How do protozoans evade the immune system?

By changing their surface antigens during their life cycle.

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What are examples of protozoan diseases?

Malaria (Plasmodium)

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What are fungi?

Multicellular

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What diseases can fungi cause?

Athlete’s foot

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What are oomycetes?

Fungus-like organisms with cellulose walls and motile spores.

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How do oomycetes infect?

By releasing enzymes that digest plant tissues and suppress immune responses.

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What are parasitic worms?

Flatworms and roundworms that live inside animal hosts.

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What do parasitic worms do to the immune system?

Suppress the host’s immune response.

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What are arthropods in disease?

Vectors like ticks and mosquitoes that transmit pathogens.

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How do arthropods help pathogens?

Their saliva inhibits inflammation

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What are viruses?

Non-living intracellular parasites made of RNA or DNA in a protein coat.

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How do viruses reproduce?

By hijacking a host cell's machinery to make copies of themselves.

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What is a virus capsid?

The protein coat surrounding a virus's genetic material.

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What are enveloped viruses?

Viruses that bud out of the host cell

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How do symptoms differ with enveloped viruses?

They cause longer-lasting infections (e.g.

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What is a retrovirus?

A virus with RNA and reverse transcriptase (e.g.

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What are viroids?

Tiny circular RNA molecules without protein coats that infect plants.

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What do viroids infect?

Plants such as potatoes

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What are prions?

Infectious proteins that cause other proteins to fold incorrectly.

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What diseases are caused by prions?

CJD and kuru.