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Key topics covered for each mental health condition
Diagnostic Criteria
Neurobiology
Pharmacotherapeutic interventions
Non-Pharmacotherapeutic interventions (CBT, DBT, MI, SFT, MBSR))
Nursing assessment, planning, and intervention
Cultural perspectives/experiences of mood, anxiety, and trauma-related conditions
Mood disorders
Nearly 1 in 5 people will experience a major depressive episode at some point in their lives
Mood disorders are prevalent and disabling, with high economic burden for society
Types of Mood Disorders (DSM-5, 2013)
Major Depressive Disorder (MDD)
Bipolar I Disorder
Bipolar Disorder
Persistent depressive disorder (dysthymia)
Cyclothmic disorder
Premenstrual dysphoric disorder
Mood disorders: Neurobiology
Genes
Psychosocial adversity in childhood
Ongoing or recent psychosocial stress
Monoamine neurotransmitters
Norepinephrine (Monoamine neurotransmitters- Mood disorders:Neurobiology)
excitatory, generating and maintaining mood states, bipolar disorder more epinephrine
Thought to play a role in anxiety
Serotonin (Monoamine neurotransmitters- Mood disorders:Neurobiology)
excitatory, emotions, sensory perception, plays role in anxiety
Dopamine (Monoamine neurotransmitters- Mood disorders:Neurobiology)
excitatory, stimulates natural feel good mechanisms, see in schizophrenia and parkinson's disease
How is a diagnosis of clinical depression different from sadness
It is sadness +
Depends on how long
Lack of feeling enjoyment
Change in lifestyle
Can display happiness during depression
Physiological changes
Major Depressive Disorder: diagnostic criteria (DSM-5, APA)
An individual must be experiencing five or more symptoms during 2 week period at least one of the symptoms should be either (1) depressed mood or (2) loss of interest or pleasure in the same 2-week period
Symptoms cause clinically significant distress or impairment in social, occupational or other important areas of functioning
Episode not attributable to physiological effects of a substance or another medical condition
Episode not better explained by schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder, or other psychotic disorder
No history of manic hypomanic episode
Symptoms (Major Depressive Disorder: diagnostic criteria DSM-5, APA)
An individual must be experiencing five or more symptoms during 2 week period at least one of the symptoms should be either (1) depressed mood or (2) loss of interest or pleasure in the same 2-week period
Depressed mood
Loss of interest/pleasure
Weight loss or gain
Insomnia or hypersomnia
Psychomotor agitation or retardation- increase or decrease in psychomotor activity i.e fidgeting, or sluggishness
Fatigue
Feeling of worthlessness or excessive/inappropriate guilt
Decreased concentration
Thoughts of death/suicide
Depression: pharmacotherapeutic interventions: Antidepressants
Increase activity of neurotransmitters in the brain which help to lessen the symptoms of depression and anxiety
Work best when combined with psychotherapy, social support and self care
Two in three people with MDD eventually achieve lasting symptoms remission with conventional antidepressants and therapy
Dopamine (Depression: pharmacotherapeutic interventions: Antidepressants)
influences decision making, influences motivation , influences arousal, signals pleasure and reward
Norepinephrine (Depression: pharmacotherapeutic interventions: Antidepressants)
influences alertness, influences motor function, regulates blood pressure, regulates heart rate
Serotonin (Depression: pharmacotherapeutic interventions: Antidepressants)
regulates mood, regulates appetite, regulates sleep, regulates social behaviour, regulates sexual desire
SSRI (selective serotonin re uptake inhibitors) (Drugs to treat Mood, Anxiety, Trauma Disorders)
Sertraline
Fluoxetine
Paroxetine
Citalopram
SNRI(serotonin,norepinephine reuptake inhibitor)(can be selective)(Drugs to treat Mood, Anxiety, Trauma Disorders)
Venlafaxine
Duloxetine
Desvenlafaxine
Levomilnacipran
Non selective cyclics( inhibit serotonin and norepinephrine reuptake along with other neurotransmitters(Drugs to treat Mood, Anxiety, Trauma Disorders)
Amoxapine
Amtriptyline
Imipramine
Doexpin
MAOI(Monoamine oxidase inhibitor (Drugs to treat Mood, Anxiety, Trauma Disorders)
Isocarboxazid
Phenelzine
Tranycypromine
Selegline
NDRI(Norepinephrine-dopamine reuptake inhibitor) (Drugs to treat Mood, Anxiety, Trauma Disorders)
Bupropion
NaSSA(noradrenergic and specific serotonergic antidepressant): (Drugs to treat Mood, Anxiety, Trauma Disorders)
Mirtazapine
SARI(Serotonin antagonist and reuptake inhibitor)(Drugs to treat Mood, Anxiety, Trauma Disorders)
Trazodone
Nefazodone
Mood disorders Pharmacotherapeutic interventions
Antidepressants
Ketamine infusion
Esktamine Treatment
Drugs to treat Mood, Anxiety, Trauma Disorders
SSRI (selective serotonin re uptake inhibitors)
SNRI(serotonin,norepinephine reuptake inhibitor)(can be selective)
Non selective cyclics (inhibit serotonin and norepinephrine reuptake along with other neurotransmitters)
MAOI(Monoamine oxidase inhibitor)
NDRI(Norepinephrine-dopamine reuptake inhibitor):
NaSSA(noradrenergic and specific serotonergic antidepressant):
SARI(Serotonin antagonist and reuptake inhibitor):
SSRI (selective serotonin re uptake inhibitors) (Side effects of Antidepressant Medications by class)
nausea
vomiting
diarrhea
weight gain
dry mouth
headaches
anxiety
sedation
decrease in sexual desire and response
SNRI(serotonin,norepinephine reuptake inhibitor)(can be selective): (Side effects of Antidepressant Medications by class)
nausea
drowsiness
dizziness
nervousness
fatigue
loss of appetite
decrease in sexual desire and response
increase in blood pressure
Serotonin syndrome (Side effects of Antidepressant Medications by class)
should go away after couple of days
agitation and restlessness
high bp
intense nightmares
dialated pupils
loss of muscle control
insomnia
heavy sweating
shivering and goose bumps
Can happen if you wean of drug to quick, or take new dosage
Non selective cyclics( inhibit serotonin and norepinephrine reuptake along with other neurotransmitters) Side effects of Antidepressant Medications by class)
dry mouth
tremors
constipation
sedation
blurred vision
difficulty urinating
weight gain
dizziness
MAOI(Monoamine oxidase inhibitor) (Side effects of Antidepressant Medications by class)
orthostatic hypotension
insomnia
swelling
weight gain
Note: drug (e.g some cold and allergy) and food interactions (tyramine)
NDRI(Norepinephrine-dopamine reuptake inhibitor)(Side effects of Antidepressant Medications by class)
jitteriness
insomnia
NDRI(Norepinephrine-dopamine reuptake inhibitor) (Side effects of Antidepressant Medications by class)
drowsiness
weight gain
SARI(Serotonin antagonist and reuptake inhibitor)(Side effects of Antidepressant Medications by class)
nausea
weakness/tiredness
dizziness
nightmares
dry mouth
changes in appetite or weight
blurred vision
stuffy nose
Some side effects are good if goal is to get sleep
Ketamine infusion (Mood disorders: pharmacological interventions)
An invasive treatment for treatment resistant depression that stimulates a rapid increase in glutamate
Glutamate helps strengthens and restore vital neural connections and pathways in the regions of the brain that are most impaired by depression
New connections help induce beneficial changes in brain circuit function
is administered IV in subanesthetic doses (0.5 mg/kg over 4 min) in an anesthetic care unit under medical supervision
Benefits of Ketamine Infusion (Mood disorders: pharmacological interventions)
Offers fast acting symptom relief (within hours).
Has anti-sucidal properties
Well tolerated and safe
Drawbacks of Ketamine Infusion (Mood disorders: pharmacological interventions)
Requires access to operating theater
Common side effects may include high blood pressure and slowed breathing
Serial inclusions may be required to maintain treatment effect
Esketamine Treatment (Mood disorders: pharmacological interventions)
A non-invasive treatment for individuals with treatment resistant depression who have failed to antidepressant trials of adequate dosages and durations
increases connections/synapses between brain cells
Administered intranasally in an outpatient setting under medical supervision
Provides a rapid acting anti-depressive response that can last 3-14 days
Benefits of Esketamine treatment (Mood disorders: pharmacological interventions)
Producers rapid acting anti-depressive response
Has anti-suicidal properites
Antidepressive response lasts an average of 3-14 days
Drawbacks of Esketamine treatment (Mood disorders: pharmacological interventions)
Common side effects include temporary sedation, trouble with attention, judgement and thinking
Initial treatment involves 6 infusions spread out of 3 weeks
May require repeated treatments to maintain anti-depressive and anti-suicidal effects in continuation phase of treatment
Bipolar & related disorders
Type 1 Bipolar disorders
Type 2 Bipolar disorder
Type 1 Bipolar disorder
Manic episodes
Distinct period(s) elevated mood + energy
Type 2 Bipolar disorder
Depressive episodes
Hypo-Mania
Bipolar I Disorder: diagnostic criteria (DSM-5, APA)
Distinct period of abnormally and persistently elevated, expansive or irritable mood and abnormally and persistently increase goal-directed activity or energy, lasting at least 1 week and present most of the day, nearly every day
During the period of mood disturbance and increased energy or activity 3 or more of the following symptoms:
The mood disturbances is sufficiently severe to cause marked impairment in social or occupational functioning or to necessitate hospitalization to prevent harm to self or others, or there are psychotic features
The episode is not attributable to the physiological effects of a substance
Symptoms (Bipolar I Disorder: diagnostic criteria DSM-5, APA)
During the period of mood disturbance and increased energy or activity 3 or more of the following symptoms:
Inflated self-esteem or grandiosity
Decreased need for sleep
More talkative than usual or more pressure to keep talking
Flight of ideas or subjective experience that thoughts are racing
Distractability
Increase in goal-directed activity
Excessive involvement in activities that have high potential for painful consequences
Bipolar II Disorder: diagnostic criteria (DSM-5, APA)
Criteria have been met for at least one hypomanic episode or at least one major depressive episode
There has never been a manic episode
The occurrence of the hypomanic episode (s), and major depressive episode(s) is not better explained by schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder or other specified or unspecified schizophrenia spectrum and other psychotic disorder
The symptoms of depression or the unpredictability caused by frequent alternation between periods of depression and hypomanic caus e clinically significant distress or impairment in social, occupational or other important areas of functioning
Bipolar 1 and 1 disorders: pharmacotherapeutic interventions: mood stabiliizers
Naturally occurring
Anticonvulsants
Adjective anticonvulsants
Naturally occurring (Bipolar 1 and 1 disorders: pharmacotherapeutic interventions: mood stabilizers )
Lithium
Anticonvulsants (Bipolar 1 and 1 disorders: pharmacotherapeutic interventions: mood stabilizers )
Carbamazepine
Divalproex
Lamotrigone
Helps to slow rapid cycling experienced during manic episodes
Adjective anticonvulsants
Gabapentin
Topiramate
Lithium (side effects of frequently used mood stabilizers for Bipolar 1&2)
Common side effects include increased thirst and urination, nausea, weight gain, fine trembling of the hands
Less common side effects can include tiredness, vomiting, and diarrhea, blurred vision, impaired memory, difficulty concentrating, skin changes, slight muscle weakness, thyroid and kidney function changes
Divaproex/Valproic (side effects of frequently used mood stabilizers for Bipolar 1&2)
Common side effects include drowsiness, dizziness, nausea and blurred vision
Less common side effects are vomiting, mild cramps, muscle tremor, mild hair loss, weight gain, bruising or bleeding, liver problems, changes in menstrual cycle in people who identify as women
Important to track blood levels-too high means more side effects
Carbamazepine(side effects of frequently used mood stabilizers for Bipolar 1&2)
Common side effects include dizziness, drowsiness, nausea and blurred vision, confusion, muscle tremor, nausea, vomiting or mild cramps, increased sensitivity to sun, skin sensitivity and rashes and poor coordination
A rare bur dangerous side effect is reduced blood cell counts, soreness of the mouth, gums or throat, mouth ulcers or sores and fever or flu like symptoms can be a side effect
Important to track blood levels- too high means more side effects
Lamotrigine (side effects of frequently used mood stabilizers for Bipolar 1&2)
Common side effects include fever, dizziness, drowsiness, blurred vision, nausea, vomiting or mild cramps, headache and skin rash
A rare but dangerous side effect is a severe skin rash
Mood disorders: Non-pharmacological interventions
Electroconvulsive Therapy (ECT)
Transcranial Magnetic stimulation (TMS)
Cognitive restructuring
Eye movement Desensitization & Reprocessing (EMDR)
Electroconvulsive Therapy (ECT) (Mood disorders: Non-pharmacological interventions)
An invasive treatment for severe mania, severe depression, treatment refractory depression, catatonia and treatment resistant schizophrenia
Small electric currents are passed through the brain intentionally triggering a brief seizure while an individual is under anesthetic
ECT brings about neurophysiological and neurochemical changes in the brain
The procedure takes about 5 to 10 minutes, with added time for preparation and recovery
The changes in brain chemistry can result in improvement after as few as 6 treatments
Benefits of Electroconvulsive Therapy (ECT) (Mood disorders: Non-pharmacological interventions)
Mood stabilizing property is superior to pharmacotherapy for depressive episodes, manic episode and mixed episode in bipolar disorder
Can return to usual activity a few hours after the procedure
Can result in rapid symptom improvement
Can be offered for inpatients and outpatients
Drawbacks of Electroconvulsive Therapy (ECT) (Mood disorders: Non-pharmacological interventions)
Requires sedation with anesthesia in hospital
May cause low mild transient side effects including confusion, retrograde amnesia, nausea, headache, jaw pain or muscle ache
May cause medical complications associated with anesthesia
Transcranial Magntic Stimulation (TMS) (Mood disorders: Non-pharmacological interventions)
A non-invasive treatment for treatment refractory depression and bipolar disorder
Uses targeted magnetic pulses, similar to those used in an MRI machine to activate parts of the brain involved in mood regulation in the dorsolateral prefrontal cortex
During a secession, a helmet containing an electromagnetic coil is placid on the head to stimulate targeted regions of the brain
Most people see dramatic improvements in depressive symptoms after four weeks- six weeks
Benefits of Transcranial Magntic Stimulation (TMS) (Mood disorders: Non-pharmacological interventions)
Well tolerated- not painful or disruptive
No hospitalization or anesthesia required
Nu systemic side effects
No memory loss
Drawbacks Transcranial Magntic Stimulation (TMS) (Mood disorders: Non-pharmacological interventions)
Common side effects may include headache, scalp discomfort at the site of stimulation, tingling and light headedness spasms of facial muscles
Uncommon side effects can include seizures and mania in people with bipolar disorder
Treatment may not be effective for everyone
Psychotherapy: Mood disorders: Non-pharmacological interventions
Cognitive therapy
Behavioural therapy
Cognitive behavioural therapy
Psychodynamic therapy
Cognitive therapy (Psychotherapy: Mood disorders: Non-pharmacological interventions)
Short term
Focused on changing negative thought patterns (cognitive distortions) that contribute to depression
Behavioural therapy (Psychotherapy: Mood disorders: Non-pharmacological interventions)
Short term
Focused on changing behaviours that contribute to depression
Cognitive behavioural therapy (Psychotherapy: Mood disorders: Non-pharmacological interventions)
Short term
Focused on addressing negative thought patterns and behaviors that contribute to depression
Psychodynamic therapy (Psychotherapy: Mood disorders: Non-pharmacological interventions)
Longer term
Focused on exploring unconscious conflicts often originating from childhood and the impact they have on depression
Types of common cognitive disorders
Mind reading
Negative focus
Catastrophizing
Labelling
Should-thinking
Overgeneralizing
Emotional reasoning
Fortune telling
Personalization
Owning the truth
Just-world thinking
Control fallacy
Should-thinking (Types of common cognitive disorders)
when you have rules or expectations how things or people should be/ act
Overgeneralizing (Types of common cognitive disorders)
when a single negative event occurs and you believe it is a pattern
Emotional reasoning (Types of common cognitive disorders)
when you believe that how you feel is evidence or reflects reality
Personalization (Types of common cognitive disorders)
when you feel personally responsible or guilty for things you can’t control
Owning the truth (Types of common cognitive disorders)
when you are certain you are right and your opinion is the truth
Just-world thinking (Types of common cognitive disorders)
when you assume that everything in the world will be balanced fairly
Control fallacy (Types of common cognitive disorders)
When you assume you can control everything that happens in your life
Mood disorders: Nursing Assessment
Screening
Assessment
Mental status examination
Suicide risk assessment
Screening (Mood disorders: Nursing Assessment)
Quick inventory of depressive Symptomatology self report (QIDS-SR)
General behaviour inventory (GBI)
Assessment (Mood disorders: Nursing Assessment)
Mood disorder questionnaire (MDQ)
Beck Depression Inventory
Hamilton Depression Rating scale (HAM-D)
Patient Health Questionnaire (PHQ-9)- can be used as to view how things change
Nursing interventions (Mood disorders)
Psychoeducation
Facilitating individual psychotherapy
Monitoring service delivery
Skill teaching-illness self management
Facilitating group psychotherapy- making sure these are only done with proper education
Medication monitoring, management & administration
Supportive counselling
Individual & system level advocacy
Resource matching and referring
Family support & education
Crisis prevention & intervention
Cultural perspectives & Experiences (Mood disorders)
Culture affects tee way we express our thoughts emotions and behaviours
There are cultural differences in the way depression is manifested and treated
One of the main differences seen across cultures is the way depression and mania are expressed
Anxiety disorders
Most prevalent psychiatric disorders associated with a high burden of illness
Nearly 1 in 4 people will experience an anxiety disorder at some point in their lives
Prevalence of different types of anxiety disorders (DSM-5,2013)
Specific phobia (9.1%)
Panic disorder (6%)
Social anxiety disorder (2.7%)
Agoraphobia (0.9%)
Generalized anxiety disorder (2.2%)
Separation anxiety disorder (4%)
Neurobiology (Anxiety disorders & PTSD)
Genes
Psychosocial adversity in childhood
Ongoing or recent psychosocial
Norepinephrine
Serotonin
Dopamine
Specific phobia: Diagnostic criteria (DSM-5,APA)
Extreme anxiety experienced when anticipating exposure or being exposed to feared stimulus
Five categories of specific phobias:
Animal type (spiders,snakes, dogs)
Natural environment type (tornadoes, heights, water, fire)
Blood injection type (needles, medical procedures)
Situational type (flying on a plane, enclosed spaces)
Other type (phobias that do not fit into the previous four categories
Panic disorder: Diagnostic criteria (DSN-5,APA)
Extreme surge of fear and discomfort due to perceived loss of control
Physical symptoms may signal the presence of a panic attack including:
Dizziness
Nausea
Racing heart
Shaking trembling
Sweating
Chills
Unsteadiness
Shortness of breath
Sensation of choking
Chest pain
Abdominal pain
Fear of losing control
Fear of dying
Social anxiety disorder; diagnostic criteria (DSM-5,APA)
Extreme fear of social situations
Extreme fear of criticism or scrutiny by others in social interactions
Intense fear often leads to avoidance of the social situation
Intense fear can cause impairments in school, work, relationships
Obsession (What is OCD?)
Recurrent persistent intrusive unwanted thoughts
Compulsions (What is OCD?)
Repetitive behaviours or mental acts that the person is driven to perform in response to the obsessive thought
Types of OCD
Body dysmorphic
Hoarding
Trichotillomania- Hair pulling disorder
Excoriation- skin picking
Obsessive compulsive disorder defined
Behaviours or mental acts are aimed at preventing or reducing anxiety or distress,* or preventing some dreaded event or situation, however these behaviours or mental acts are not connected in a realistic way with what they are designed to neutralize or prevent, or are clearly excessive
Obsessive compulsive disorders: Diagnostic criteria
The obsessions or compulsions are time-consuming or cause clinically significant distress or impairment in social, occupational or other important areas of functioning
The obsessive compulsive symptoms are not attributable to the physiological effects of a substance
Recurrent and persistent thoughts, urges or images that are experienced, at some time during the disturbance as intrusive and unwanted that in most individuals cause marked anxiety or distress
The individual attempts to ignore or suppress such thoughts urges or images to neutralize them with some thought or action
Manifestations of OCD
Repetitive behaviours (hand washing, ordering, checking) or mental acts (praying, counting, repeating words silently) that the individual feels driven to perform in response to an obsession or according to rules that must be applied rigidly
SSRI (selective serotonin reuptake inhibitors) (Drugs to treat anxiety disorders & PTSD)
Citalopram (Celexa)
Sertraline (Zoloft)
Fluoxetine (Prozac)
Paroxetine (Paxil)
Citalopram (Celaxa)
Fluvoxamine (Luvox)
SNRI (serotonin,norepinephine reuptake inhibitor)(can be selective) (Drugs to treat anxiety disorders & PTSD)
Venlafaxine (Effexor)
Cympalita (Duloxetine)
TCA (Tricyclic antidepressant) (Drugs to treat anxiety disorders & PTSD)
Comipramine (Anafranil)
Imipramine (Tofranil)
Desipramine (Norpramin)
Bensodiazepines (Drugs to treat anxiety disorders & PTSD)
Clonaspam (rivotril)
Alprazolam (XANAX)
Lorazepam (Ativan)
Other medications (Drugs to treat anxiety disorders & PTSD)
Buspirone (Buspar)
Anticholergics
Beta blockers
Side effects of benzodiazepines
Common side effects include drowsiness, sedation, dizziness and loss of balance
Effects are more serious when combined with alcohol or with other sedative medications
Non-pharmacological interventions (Anxiety disorders)
Cognitive behaviour therapy
Exposure & Response Prevention
Cognitive behaviour therapy (Non-pharmacological interventions: Anxiety disorders)
the evidence-based treatment of choice for people living with anxiety disorders
The aim is to help the client to become aware of inaccurate or negative thinking so that they can view challenging situations more clearly and respond to them in a more effective way
can be helpful either alone or in combination with other therapies
Benefits of Cognitive behaviour therapy (Non-pharmacological interventions: Anxiety disorders)
Helps individuals with illness self -management
Has a role in preventing relapse of symptoms of anxiety
Drawbacks of Cognitive behaviour therapy (Non-pharmacological interventions: Anxiety disorders)
Individuals may feel emotionally uncomfortable at times when they are exploring painful feelings, emotions and experiences
Individuals may feel physically drained, cry, get upset or feel angry during challenging sessions
Exposure therapy (Non-pharmacological interventions: Anxiety disorders)
An evidence-based treatment for people living with obsessive compulsive disorder, panic disorder and agoraphobia
consists of habituating the client degree by degree to the feared situations in imagination and then in vivo
The aim is to obtain a habituation of emotional responses and the extinction of avoidance behaviors which are reinforced by anxiety
treatment is most effective when used in combination with antidepressants
Benefits of Exposure therapy (Non-pharmacological interventions: Anxiety disorders)
Exposure to feared situations in imagination before being exposed to them in vivo reduces anxiety responses
Drawbacks of Exposure therapy (Non-pharmacological interventions: Anxiety disorders)
Completion of homework exercises between sessions is important to optimize treatment benefits
Services may not be available through publicly funded health care system
Cognitive Restructuring (Non Pharmacological interventions: Mood disorders)
An evidence-based therapy for anxiety disorders
Therapy has four key components:
Breathing retraining to help to control the physiological sensations resulting in panic attacks
Teaching abdominal breathing (Valsalva technique) to control tachycardia
Cognitive restructuring to modify misinterpretations of bodily sensations and challenge the “danger” cognitive schemata
Graded exposure through behavioural experiments to modify agoraphobia
Treatment typically includes 15 to 20 sessions