Blood Bank BASIC Antibody STRUCTURE Lecture 5

0.0(0)
Studied by 0 people
call kaiCall Kai
Locked
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
GameKnowt Play
Card Sorting

1/21

encourage image

There's no tags or description

Looks like no tags are added yet.

Last updated 11:12 PM on 9/9/26
Name
Mastery
Learn
Test
Matching
Spaced
Call with Kai
Chat

No analytics yet

Send a link to your students to track their progress

22 Terms

1
New cards

What are immunoglobulins (Ig)?

ANTIBODIES specifically glycoproteins

2
New cards

What are Immunoglobulins composed of?

Protein + Carbohydrate

3
New cards

What are the 5 major classes of immunoglobulins?

GMADE

IgG, IgM, IgA, IgD, IgE

4
New cards

How many chains do immunoglobulins have?

4 total chains

2 - heavy chains

2 - light chains

HELD TOGETHER by noncovalent forces

5
New cards

What is the role of the heavy chains in immunoglobulins?

Identify the antibody class

6
New cards

What are the two types of light chains?

Kappa OR lambda

<p>Kappa OR lambda </p>
7
New cards

What is the FAB region of the immunoglobulins (antibody)?

VARIABLE REGION where specific antigens bind

<p>VARIABLE REGION where specific antigens bind </p>
8
New cards

What is the Paratope on the immunoglobulins?

Paratope = actual site of antigen binding LEGO HANDS

9
New cards

What is the FC region of the antibody (immunoglobulins)?

The Fc region dictates the BIOLOGICAL FUNTIONS of the antibody

CONSTANT REGION

<p>The Fc region dictates the BIOLOGICAL FUNTIONS of the antibody </p><p>CONSTANT REGION </p>
10
New cards

What is the HINGE region of the antibody?

Allows for flexibility of the antibody ONLY FOR IgG, IgD, and IgA

<p>Allows for flexibility of the antibody ONLY FOR IgG, IgD, and IgA </p>
11
New cards

Which immunoglobulins do not have a hinge region?

IgM and IgE

IgM is TOO BIG

12
New cards

What is the purpose of the CARBOHYDRATE portion of the immunoglobulins

Support solubility, for protection, and ENHANCES FC FUNCTION

<p>Support solubility, for protection, and ENHANCES FC FUNCTION </p>
13
New cards

Which kind of bonds hold the Fc and Fab region together?

DISULFIDE BONDS

14
New cards

How does the enzyme PAPAIN cut the antibody?

SPLITS THE ARMS

Fc region stays in tact, the two double arms are separated

FAB ARMS SEPARATE

<p>SPLITS THE ARMS </p><p>Fc region stays in tact, the two double arms are separated</p><p>FAB ARMS SEPARATE </p>
15
New cards

How does the enzyme PEPSIN cut the antibody?

Fab region stays together, but the Fc heavy chains are cut

FAB ARMS STAY TOGETHER

<p>Fab region stays together, but the Fc heavy chains are cut</p><p>FAB ARMS STAY TOGETHER </p>
16
New cards

What is an isotype?

Isotype = Ig CLASS / Subclass


17
New cards

Where are the Isotype sequences found?

CONSTANT regions of heavy chain

18
New cards

What is an Allotype?

SAME Ig CLASS, but different version with MINOR AMINO ACID VARIATIONS

Different between people of same species

Version A and Version B

19
New cards

Where can Allotype variations be found?

Constant regions of IgG subclasses

One IgA subclass

LAMDA LIGHT CHAIN

20
New cards

What is an Idiotype?

Variation that gives each antibody DIFFERENT SPECIFICITY for an antigen

21
New cards

Where are the Idiotype regions found?

VARIABLE REGIONS

22
New cards

What is the true structure of an antibody?

A compact 3D structure

REMEMBER THEY ARE PROTEINS SO THEY FOLD IN