CNPT2 Exam 3 Drugs

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1

Temazepam brand

Restoril

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2

Temazepam class

Benzodiazepine

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3

Temazepam use

Insomnia

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4

Temazepam MOA

Binds to benzodiazepine receptors, enhances GABA effects

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5

Temazepam dose

7.5-30 mg PO qHS PRN

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6

Temazepam contraindications

Avoid abrupt withdrawal

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7

Temazepam BBW

Use with opioids may result in profound sedation, respiratory depression, coma, or death

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8

Clonazepam brand

Klonopin

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9

Clonazepam class

Benzodiazepine

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10

Clonazepam use

Seizure disorders, panic disorder

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11

Clonazepam MOA

Binds to benzodiazepine receptors, enhances GABA effects

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12

Clonazepam dose

0.5-5 mg PO TID

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13

Clonazepam contraindications

Hepatic impairment, avoid abrupt withdrawal

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14

Clonazepam BBW

Use with opioids may result in profound sedation, respiratory depression, coma, or death

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15

Lorazepam brand

Ativan

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16

Lorazepam class

Benzodiazepine

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17

Lorazepam use

Anxiety, status epilepticus

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18

Lorazepam MOA

Binds to benzodiazepine receptors, enhancing GABA effects

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19

Lorazepam dose

2-6 mg PO/IM/IV divided BID or TID

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20

Lorazepam contraindications

Sensitivity to polyethylene glycol, respiratory impairment, sleep apnea, avoid abrupt withdrawal

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21

Lorazepam BBW

Use with opioids may result in profound sedation, respiratory depression, coma, or death

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22

Diazepam brand

Valium, Diastat

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23

Diazepam class

Benzodiazepine

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24

Diazepam use

Seizure disorders, anxiety, sedation

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25

Diazepam MOA

Binds to benzodiazepine receptors, enhances GABA effects

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26

Diazepam dose

2-10 mg PO BID-QID or 5-10 mg IM/IV q3-4h

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27

Diazepam contraindications

Avoid abrupt withdrawal

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28

Diazepam BBW

Use with opioids may result in profound sedation, respiratory depression, coma, or death

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29

Alprazolam brand

Xanax

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30

Alprazolam class

Benzodiazepine

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31

Alprazolam use

Anxiety, panic disorder

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32

Alprazolam MOA

Binds to benzodiazepine receptors, enhances GABA effects

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33

Alprazolam dose

IR: 0.5-3 mg PO TID, ER: 3-6 mg PO qD

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34

Alprazolam contraindications

Avoid abrupt withdrawal

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35

Alprazolam BBW

Use with opioids may result in profound sedation, respiratory depression, coma, or death

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36

Trazodone brand

Trazodone

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37

Trazodone class

Serotonin reuptake inhibitor antidepressant

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38

Trazodone use

Major depressive disorder, insomnia

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39

Trazodone MOA

Antagonizes serotonin 5-HT2A/C and alpha-1 adrenergic receptors, inhibits serotonin reuptake

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40

Trazodone dose

50-100 mg PO BID or TID

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41

Trazodone contraindications

Avoid abrupt withdrawal

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42

Trazodone BBW

May cause suicidal thoughts in children and young adults

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43

Hydroxyzine brand

Atarax, Vistaril

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44

Hydroxyzine class

H1 antihistamine

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45

Hydroxyzine use

Anxiety, pruritus, urticaria

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46

Hydroxyzine MOA

Non selectively antagonizes central and peripheral histamine H1 receptors

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47

Hydroxyzine dose

25-100 mg PO/IM q4-6h PRN

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48

Hydroxyzine contraindications

QT prolongation, hypersensitivity to cetirizine or levocetirizine

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49

Hydroxyzine BBW

None

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50

Zolpidem brand

Ambien

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51

Zolpidem class

Anxiolytic, hypnotic

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52

Zolpidem use

Short term insomnia

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53

Zolpidem MOA

Interacts with GABA-benzodiazepine receptor complexes

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54

Zolpidem dose

IR: 5-10 mg PO qHS, ER: 6.25-12.5 mg PO qHS

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55

Zolpidem contraindications

Alcohol use, hepatic impairment, history of complex sleep behavior

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56

Zolpidem BBW

Complex sleep behaviors may occur including sleep walking, sleep driving, and other activities

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57

Ramelteon bran

Rozerem

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58

Ramelteon class

Sedative/hypnotic, melatonin receptor agonist

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59

Ramelteon use

Delirium

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60

Ramelteon MOA

Potent selective agonist of melatonin receptors (MT1, MT2), little affinity for MT3, acts within the suprachiasmatic nucleus of the hypothalamus

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61

Ramelteon dose

8 mg PO within 30 minutes of bedtime

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62

Ramelteon contraindications

Avoid alcohol

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63

Ramelteon BBW

None

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64

Eszopiclone brand

Lunesta

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65

Eszopiclone class

Non-benzodiazepine hypnotic

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66

Eszopiclone use

Insomnia

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67

Eszopiclone MOA

Interacts with GABA-receptor complexes coupled to binding domains close to benzodiazepine receptors

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68

Eszopiclone dose

1-3 mg PO qHS

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69

Eszopiclone contraindications

Use with caution in patients with a history of drug dependence

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70

Ezoclipone BBW

None

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