8.2 Transport of O2/CO2

Haemoglobin
> made of _ polypeptides (each has 1 h__ group that can bind to 1 __)
>> Hb + 4O₂ → HbO₈ (o__)
> m__ O₂ is binded when there is a h__ p__ p__ of O₂
> when 1 O₂ binds w/ 1 haem group, the whole __ s__ changes, making it e__ for a 2nd O₂ to bind ;; when that binds it changes shape = even easier

4, haem, O2, oxyhaemoglobin, more, higher partial pressure, 3D shape, easier

The B__ Shift
> CO₂ increases a__ (conc. of __)
> CO₂ + __ ←(__ __)→ H__ (c__ a__)
> this dissociates: H₂CO₃ ←→ __^__ + H__^__ (h__ ion)
> h__ can bind w/ H⁺ → h__ acid & r__ the __ it was carrying
> thus high p__ p__ of __ = more O₂ unloaded

Bohr, acidity, H+, H2O, carbonic anhydrase, H2CO3, carbonic acid, H+, HCO3-, hydrogencarbonate, haemoglobin, haemoglobinic, release, O2, partial pressure, CO2

The Chloride Shift
> H__^__ can d__ out the r__ b__ c__ into plasma
> as __^__ can’t leave, the i__ of the cell gets too __ve, so __^__ diffuse from plasma → cell

HCO3-, diffuse, red blood cell, H+, inside, +, Cl-

the higher line has __ (higher/lower) conc of CO₂ as __ (more/less) O₂ are binded to Hb

lower, more

the lower line has __ (higher/lower) conc of CO₂ as __ (more/less) O₂ are binded to Hb

higher, less

Transport of CO₂
__% as __^__
__% combined w/ h__ → carbaminohaemoglobin
__% in soln in b__ p__

85, HCO3-, 10, haemoglobin, 5, blood plasma

CO₂ can be transported via d__
HCO₃ can be transported via f__ d__

diffusion, facilitated diffusion