Q5: Contrasting Molecular Tools – Epitranscriptomic Regulation of mRNA Contrast the roles of the m6A "Writer" complex (METTL3/METTL14) and the "Reader" protein YTHDF2 in governing mRNA metabolism. If a researcher used a small-molecule inhibitor to block the "Eraser" (FTO) in a neuronal cell line, deduce the likely effect on the half-life and stability of m6A-modified transcripts. Would this inhibition result in "RNA restructuring" via an m6A-switch mechanism, or would it primarily lead to accelerated decay?
10