auto beta receptor antagonist in class questions

t/f: there are a larger number of alpha-1 selective antagonists than alpha-2 antagonists

true

at high doses, alpha antagonists would be expected to affect cardiovasc system by

a. increasing capacitance

b. relaxing arteriolar resistance vessels

c. relaxing venous smooth muscle

d. 2 of the above

e. all of the above

e. all of the above

t/f: the prostate gland and lower urinary tract have a greater proportion of alpha-1b than alpha 1a or alpha 1d subtypes

false

t/f: alpha 1 receptor stimulation can promote cardiac growth

true

alpha 1 receptors in heart can increase growth when symp activity increases (ex: in heart failure)

all of the following about phenoxybenzamine are true EXCEPT

a. it is competitive alpha-receptor antagonist

b. it would likely decrease afterload

c. it would likely cause greater orthostatic hypotension than centrally active alpha-2 agonists

d. it is only slightly more selective for alpha-1 over alpha-2 receptors

e. HR may be augmented by prejunctional alpha-2 blockade

a.

its a NON-competitive antagonist bc it covalently binds to receptor

which of the following would likely be the best drug(s) for long term management of HTN due to pheochromocytoma

a. propranolol

b. phentolamine

c. phenoxybenzamine

d. phenoxybenzamine + metoprolol

e. phentolamine + isoproterenol

f. prazosin

d. phenoxy and metoprolol

want to block both alpha and beta

prazosin

a. is much more selective for alpha-1 than alpha-2

b. can block prejunctional alpha-2 and increase NE release

c. has a central effect that affects symp drive

d. 2 of the above

e. all of the above

d. 2 of the above-> a and c

prazosin is very selective. would not block alpha-2. does have central effect.

which of the following drugs show LOW selectivity among alpha-1 subtypes

a. terazosin

b. alfuzosin

c. tamsulosin

d. phentolamine

e. 2 of above

f. 3 of above

d. phentolamine

all others are selective

tamsulosin facilitates micturition by relaxing

a. bladder neck (including trigone)

b. prostatic uretha

c. prostatic capsule

d. 2 of above

e. all of above

e. all of the above

all of the following comments about yohimbine are true except

a. it is selective for alpha-2 receptors

b. its noncompetitive antagonist

c. crosses BBB

d. increases symp drive

e. increases peripheral release of NE per impulse

f. can increase BP and HR

b.

yohimbine is competitive. it IS selective for alpha-2 and can increase NE release by blocking pre-synaptic auto receptor on post gang neurons

all of the following comments about beta blockers are true EXCEPT they

a. attenuate exercise-induced increases in HR

b. attenuate exer-induc increases in myocardial contractility

c. prevent exer-induc increases in stroke volume

d. tend to decrease work capacity

e. inhibit epi-induced activation of glucose metabolism and lipolysis

f. can aggravate bronchospasms in sensitive individuals

c. prevent exer-induc increases in stroke volume

this is alpha-1 mech. alpha 1 cause vasoconstriction and shunts blood to heart. since this is NOT blocked, stroke volume is not affected

when you block beta receptors you will lower HR and contractility. thus this will decrease work capacity

metoprolol is a _________ beta receptor antagonist ________ additional vasodilating activity

a. non-selective, with

b. beta-1, without

c. non-selective, without

d. beta-1, with

b. beta 1 selective, without

labetalol is a _________ beta receptor antagonist ________ additional vasodilating activity

a. non-selective, with

b. beta-1, with

c. non-selective, without

d. beta-1, without

a. non-selective, with

nebivolol

a. is a beta-1 selective antagonist

b. has alpha-1 antagonist activity

c. can cause vasodilation via eNOS

d. 2 of the above

e. all of the above

d. 2 of the above- a and c

t/f: beta blockers often reduce BP in normotensive pts

false

all of the following about beta blockers are true EXCEPT

a. antagonists with ISA are more likely to decrease TPR

b. they may protect the heart from further damage

c. antagonists should be given before alpha receptor antagonists in pheochromocytoma

d. abrupt discontinuation of beta blockers can exacerbate angina

c. antagonists should be given before alpha receptor antagonists in pheochromocytoma

DO NOT GIVE BEFORE. if u give it first you can block some vasodilating mechs with beta 2 and make HTN worse