TOP 300- SEVERE REACTIONS

amoxicillin severe reactions

1) renal and hepatic failure

2) pancytopenia

augmentin severe reactions

1) renal and hepatic failure

2) pancytopenia

atazanivir severe reactions

1) allergy

2) renal failure

3) PR and OTc prolongation

4) torsades

5) choleslithis

6) L nundle branch block

azithromycin severe reactions

1) SJS

2) chest pain

3) myasthenia gravis

4) QTc prolongation

5) torsades

6) hepatitis

7) hearing loss

cefdinir severe reactions

1) increased liver enzymes

2) hypersensitivity

3) c dif

cefuroxime severe reactions

1) SJS

2) anemia

3) seizures

4) pancytopenia

5) neutropenia

cephalexin severe reactions

1) SJS

2) renal failure

3) anemia

4) neutropenia

5) seizure

chlorohexidine severe reactions

skin irritation

ciprofloxacin severe reactions

allergy

ciprofloxacin PO severe reactions

1) SJS

2) renal failure

3) anemia

4) seizure

5) neutropenia

6) thrombocytopenia

7) cardiac effects

8) liver failure

9) myasthenia gravis

10) tendon rupture

11) psychosis

12) QTC prolongation

13) peripheral neuropathy

14) CNS effects and dermatologic

clarithromycin severe reactions

1) QTC prolongation

2) SJS

3) anemia

4) neutropenia

5) thrombocytopenia

6) elevated LFTs

7) myasthenia gravis

8) hallucinations

9) nephrotoxicity

clindamycin PO severe reactions

1) QTC prolongation

2) SJS

3) esophagitis

4) pseudomembranous colitis

clindamycin topical severe reactions

none

darifenacin severe reactions

angioedema

dexlansoprazole severe reactions

1) SJS

2) rhabdo

3) acute intestinal nephritis

4) c dif

5) hypomagnesemia

6) MI

7) cutaneous and systemic lupus erythematosus

diphenoxylate/atropine severe reactions

1) pancreatitis

2) toxic megacolon

3) anaphylaxis

doxycycline severe reactions

1) esophageal ulcerations

2) hepato toxicity

3) renal toxicity

4) c dif

5) increase intracranial pressure

6) decrease growth in peds

efavirenz severe reactions

1) psychosis

2) seizures

3) hepatic failure

4) pancreatitis

5) suicidal ideations

6) fat redistribution

7) immune recon syndrome

Elbasvir/grazoprevir severe reactions

1) anemia

2) angioedema

3) hep b reactivation

4) severe hepatic disease

emtrictabine/tenofovir disoproxil severe reactions

1) bone fracture

2) lactic acidosis

3) HBV exacerbation

4) renal failure

5) immune recon syndrome

erythromycin severe reactions

1) QTC prolongation

2) arrhythmia

3) SJS

4) hepatotoxicity

5) severe AR

6) anemia

7) neutropenia

8) pancytopenia

9) seizure

esomeprazole severe reactions

1) toxic epidermal necrolysis

2) pancreatitis

3) hepatotoxicity

4) bone fracture

5) rhabdo

6) acute interstiital nephritis

7) cutanoues lupus erythematosus

8) systemic lupus erythematosus

famotidine severe reactions

1) SJS

2) inc liver enzymes

3) seizure

4) delirium

5) necrotizing enterocolitis

6) thrombocytopenia

finasteride severe reactions

1) heart failure

2) angioedema

3) allergic skin rxn

4) male breast cancer

5) prostate cancer

fidaxomicin severe reactions

1) angioedema

2) bowel obstruction

3) GI hemorrhage

fluconazole severe reactions

1) SJS

2) arrhythmias

3) adrenal suppression

4) agranulocytosis

5) seizures

6) elevated LTFs

7) hypokalemia

glecepravir/pibrentasivir severe reactions

1) severe hepatic disease

2) angioedema

3) HBV

hydroxychloroquine

1) arrhythmia's

2) cardiomyopathy

3) SJS

4) agranulocytosis

5) seizures

6) retinopathy

7) psychosis

imiquimod severe reactions

1) exfoliative dermatitis

2)hyperpigmentation

3) scrotal pain

4) urinary retention

ketoconazole severe reactions

1) rash

2) hair loss

3) AR

lansoprzole severe reactions

1) SJS

2) rhabdo

3) acute interstitial nephritis

4) c. dif

5) hypomagnesium

6) bone fractures

levofloxacin severe reactions

1) SJS

2) renal failure

3) anemia

4) neutropenia

5) thrombocytopenia

6) seizure

7) cardiac arrest

8) arrhythmias

9) liver failure

10) tendon rupture

11) psychosis

12) glucose abnormalities

13) c dif

14) peripheral neuropathy

15) CNS effects

16) severe cardiac, derm reactions

linaclotide severe reactions

1) hematochezia

2) urticaria

3) rectal hemorrhage

4) dehydration

lubiprostone severe reactions

1) hypotension

2) syncope

3) rectal hemorrhage

maraviroe severe reactions

1) coronary artery disease

2) angina

3) jaundice

4) hepatic failure

5) seizures

metoclopramide severe reactions

1) malignant HTN

2) arrhythmias

3) galactorrhea

4) amenorrhea

5) gynecomastia

6) impotence sec. to hyperprolactinemia

7) agranulocytosis

8) dystonia

9) extrapyramidal rxns

10) tardive dyskinesia

11) hallucinations

metronidazole severe reactions

1) seizures

2) ototoxicity

3) clinically insignificant dark urine

4) SJS

5) nuetrocytopenia

6) thrombocytopenia

7) neurocerebellar toxicity

minocycline severe reactions

1) hepato/renal toxicity

2) c.dif colitis

3) inc. intracranial pressure

4) dec. growth- peds

5) tissue hyperpigmentation

moxifloxacin PO severe reactions

1) SJS

2) renal failure

3) anemia

4) neutropenia

5) thrombocytopenia

6) cardiac arrhythmias

7) liver failure

8) tendon rupture

9) psychosis

10) myasthenia gravis

11) peripheral neuropathy

12) CNS effects

1) cardiac/derm rxns

moxifloxacin opthalmic severe reactions

fungal/bacterial occular superinfection

mupirpocin severe reactions

1) c dif

2) anaphylaxis

3) angioedema

nitrofurantoin severe reactions

1) hepatic failure

2) hemolytic anemia

3) interstitial lung disease

4) pulmonary toxicity

5) peripheral neuropathy

nystatin systemic severe reactions

rash

nystatin topical severe reactions

1) rash

2) SJS

omeprazole severe reactions

1) topical epidermis necrolysis

2) c dif

3) pancreatitis

4) hepatotoxicity

5) hip fracture

6) rhabdo

7) acute interstitial nephritis

8) systemic lupus eryhtamatosus

ondansetron severe reactions

1) arrhythmias

2) anaphylaxis

3) serotonin syndrome

4) torsades

pantoprazole severe reactions

1) toxic epidermal necrolysis

2) SJS

3) thrombocytopenia

4) hip fracture,

5) rhabdo

6) acute interstitial nephritis

7) cutaneous/systemic ery. lupus

penicillin severe reactions

1) severe AR

2) renal/hepatic failure

3) hemolytic anemia

phenazopyridine

1) anaphylaxis

2) methemoglobinemia

3) hemolytic anemia

4) hepatotoxicity

5) nephrotoxicity

polyethylene glycol severe reactions

1) anaphylaxis

2) dehydration

3) seizures

rabeprazole severe reactions

1) SJS

2) bone fracture

3) rhabdo

4) acute interstitial nephritis

5) increased risk of infections

raltegravir severe reactions

1) anemia

2) cerebrellar ataxia

3) depression

4) hepatitis

5) myopathy

6) nephroithiasis

7) psychmotor hyperactivity

8) renal failure

9) rhabdo

10) SJS

11) suicidal ideation/behavior

12) thrombocytopenia

13) toxic necrolysis

polymyxin B/trimethoprium severe reactions

allergy

rifamixin severe reactions

1) angioedema

2) urticaria

sofosbuvir severe reactions

1) pancytopenia

2) HBV reactivation

3) depression

4) suicidality

sucralfate severe reactions

1) bezor formation

2) diarrhea

3) GI distress

40 hyperglycemia

tamulosin severe reactions

1) angioedema

2) retinal detachement

3) priapism

tizanidine severe reactions

1) AMI

2) thrombocytopenia

3) hepatitis

4) PE

5) death

6) slow/difficult breathing when used with opiods

bactrim severe reactions

1) severe AR

2) renal failure

3) hepatic failure

4) pancytopenia

5) arrhythmias

6) SJS

7) hyperkalemia

8) hypoglycemia

9) hemolytic anemia