Androgens (MC)
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30 Terms
Androgens: Their Roles In Males
Endogenous Androgen Receptor Agonists
• Biosynthesis
Endogenous Androgen Receptor Agonists
Pharmacodynamics & binding
Androgen Receptor Agonists
SAR
Androgen Receptor Agonists
SAR (cont.)
Androgen Receptor Agonists
SAR (cont.)
Androgen Receptor Agonists
SAR (cont.)
Androgen Receptor Agonists
SAR (cont.)
Androgen Receptor Agonists
SAR (cont.)
Androgen Receptor Agonists
SAR (cont.)
Ring D: 17-OH
Androgen Receptor Agonists
SAR (cont.)
Ring D (cont.)
Androgen Receptor Agonists
SAR (cont.)
• Ring D (cont.)
Androgen Receptor Agonists
SAR (cont.)
• Rings A, B, & C
Androgen Receptor Agonists
SAR (cont.)
• Clascoterone- A PREGNANE
Endogenous Androgen Receptor Agonists
Metabolic transformations
• Testosterone
Androgen Receptor Steroidal anti-androgens
Androgen Receptor Antagonists
Non-steroidal anti-androgens
Androgen Receptor Antagonists
Non-steroidal anti-androgens
Bicalutamide (Casodex®)
Androgen Receptor Antagonists
Non-steroidal anti-androgens
Flutamide
Androgen Receptor Antagonists
Non-steroidal anti-androgens
Nilutamide (Nilandron®)
Androgen Receptor Antagonists
Non-steroidal anti-androgens
Apalutamide (Erleda® Feb., 2018)
Androgen Receptor Antagonists
Non-steroidal anti-androgens
Enzalutamide (Xtandi® July, 2018)
Androgen Receptor Non-steroidal anti-androgens antagonists (Newest addition…)
• Darolutamide (Nubega®)
5a-Reductase Inhibitors
5a-Reductase Inhibitors
SAR
5a-Reductase Inhibitor Mechanism
5a-Reductase Inhibitors
Finasteride (Proscar®, Propecia®)
5a-Reductase Inhibitors
Dutasteride (Avodart®)
5a-Reductase Inhibitors
Dutasteride (Avodart®)
• Metabolism
Effects/Risks of Anabolic Androgen Use/Abuse
(FYI)
