THC Paper #2

Prenatal THC effects on hippocampal plasticity markers

Increases NR1, mGluR5, Homer 1, CB1 receptor, HINT1; Decreases NR2A, PSD95, leading to an excitatory/inhibitory imbalance.

Behavioral deficits from prenatal THC

Decreased correct responses, increased reference errors, impaired spatial memory, increased latency to escape, reduced cognitive performance.

Effects of CBD on spatial memory

CBD administration during adolescence improves correct responses, reduces reference errors, decreases latency in tasks, and restores cognitive z-scores.

Role of NR1 and NR2A in synaptic plasticity

NR1 is essential for NMDA receptor stability; NR2A influences synaptic refinement and plasticity direction.

Adolescence as a 'window of opportunity' in therapy

Ongoing synaptic refinement and plasticity in adolescence allows interventions like CBD to potentially reprogram altered neural circuits.

Molecular abnormalities restored by CBD

CBD reduces NR1, mGluR5, Homer 1, CB1R but does not fully normalize NR2A, PSD95, or HINT1.

Excitatory/inhibitory imbalance effects

Imbalance disrupts long-term potentiation and depression, impairing learning and memory, linked to prenatal THC exposure.

Impact of prenatal THC on cognitive function

Both behavioral impairments and molecular changes demonstrate interference in hippocampal plasticity and cognitive processes.