Artificial Pancreas 4

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Last updated 2:41 PM on 4/24/26
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12 Terms

1
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What are the insulin pumps (tubed & tubeless) and glucose monitors design considerations

  • sources of error

  • risks of error

  • how would you address the errors

  • design improvements

    • therapeutic

    • aesthetic

  • priority (demographic)

<ul><li><p>sources of error</p></li><li><p>risks of error</p></li><li><p>how would you address the errors</p></li><li><p>design improvements</p><ul><li><p>therapeutic</p></li><li><p>aesthetic</p></li></ul></li><li><p>priority (demographic)</p></li></ul><p></p>
2
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What benefits/drawbacks are associated with technologies of artificial pancreas? How could these impact the monitoring of disease progression

Artificial pancreas technology can improve monitoring of diabetes by providing continuous, detailed glucose data, allowing earlier detection of deterioration and better assessment of disease progression. However, drawbacks include technical limitations, data overload, and privacy concerns, and long-term user experience must also be considered when judging benefit.

3
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What is a consideration that should be used for monitoring of condition

long-term reporting of user experience

4
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What are potential things that could be done for artificial pancreas in the future

APS (CGM & IP) will no doubt develop further and benefit users greatly. But….

  • Will we ever be able to cure type 1 diabetes? An artificial pancreas will always need an exogenous insulin supply for the pump

  • Stem cells – the dream of creating a new “biological” organ

5
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What are stem cells?

Stem cells are defined by two key features self-renewal and differentiation

<p>Stem cells are defined by two key features self-renewal and differentiation</p>
6
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Can beta cells derived from pluripotent stem cells produce insulin as efficiently as primary (normal) cells

In a study when SC-b cells were transplanted into mice they matured and showed similar function to primary beta cells after 6–10 weeks

Further research looked to produce cell clusters capable of secreting insulin and glucagon

Mature b-cells function as glucose sensors matching insulin output to plasma glucose concentration.

7
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Can we build a “biological” pancreas with stem cells?

The artificial pancreas uses electronics to measure glucose and deliver insulin, while the bioartificial pancreas uses living insulin-producing cells protected inside an implanted biomaterial device.

<p>The artificial pancreas uses electronics to measure glucose and deliver insulin, while the bioartificial pancreas uses living insulin-producing cells protected inside an implanted biomaterial device.</p>
8
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Immune therapy- can we prevent T1DM developing

Current research is looking to develop treatments that reprogramme the immune system so that it does not destroy b-cells & avoids progression to a clinical state

9
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What does T1DM involve

autoimmune destruction of B cells

10
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what are markers of disease and progression

there are a variety of autoantibodies which are clinical markers of disease and progression

11
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What is more preferable prevention or artificial pancreas

prevention would be preferable to an artificial pancreas but currently unlikely

12
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How can one target immunotherapy

Engineers and biologists have developed new methods of detecting autoantibodies- which will allow us to target immunotherapy