The BAF Complex: Mechanisms, Diversity, and Disease Implications
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8 Terms
What is the BAF complex also known as
The mammalian SWI/SNF complex.
What is the BAF complex a master regulator of
Transcriptional activity and cell fate.
What type of complex is the BAF complex
An ATP-dependent chromatin remodelling complex.
What is the primary function of the BAF complex
To manipulate the spatial positioning of nucleosomes to control DNA accessibility.
How frequently is the BAF complex mutated in human cancer
In approximately 20% of all human cancers.
What does the mutation frequency of the BAF complex underscore
Its status as one of the most frequently mutated entities in human disease.
Besides cancer, in what other types of conditions are BAF complex mutations found
Several developmental syndrom