[CA2 M4]: PCOL Ans

Class: Timolol

Non-selective Beta Blocker

Class: arecoline

Ditect acting cholinergic agonist

Adrenergic antagonist: Not used for HTN alone as it can cause bradycardia leading to cardiac arrest or heart block

Non-selective BB

Drug that inhibits formation of L-DOPA

Metyrosine

Drug that inhibits the storage of dopamine (VMAT inhibitor)

Reserpine

Drugs that inhibit release of NE (3)

- guanethedine

- guanadrel

- bretrylium

Drugs that inhibit reuptake process (3)

- TCA

- Cocaine

- Reboxitine

Drug that inhibits uptake of choline

Hemicholinium

Drug that inhibits storage of ach

Vesamicol

Drug that inhibits release of ach

Botulinum toxin

Class: Epinephrine

Alpha and beta agonists (direct)

Class: Norepinephrine

Alpha and beta agonists (direct)

Class: dopamine

Alpha and beta agonists (direct)

Class: phenylephrine

Alpha 1 agonist

Class: phenylpropanolamine, pseudoephedrine

Alpha 1 agonist

Class: clonidine

Alpha 2 agonist

Class: methyldopa

Alpha 2 agonist

Class: guanfacine

Alpha 2 agonist

Class: guanabenz

Alpha 2 agonist

Class: oxymetazoline

Alpha 1 and 2 agonist

Class: dobutamine

Beta 1 agonist

Class: SABA and LABA

Beta 2 agonist

SABA/LABA: Albuterol/Salbutamol

SABA

SABA/LABA: Terbutaline

SABA

SABA/LABA: Metaproterenol

SABA

Class: acetylcholine

Ditect acting cholinergic agonist

Signs: diplopia. ptosis

Myasthenia gravis

Cholinergic antagonist: initially stimulate then block ganglia

Nicotine

Cholinergic antagonist: rarely used for HTN due to lack of selectivity

hexamethonium, mecamylamine, trimetaphan

Reverses action of non-depolarizing NMB by commanding it to leave (exact reversal agent)

Sugammadex

Adrenergic agonist: S/E are HTN, arrhythmia, MI, pulmonary edema/hemorrhage

Epinephrine/adrenaline

Which receptor does dopamine activate at moderate dose?

Beta receptors

Which receptor does dopamine activate at high dose?

Alpha receptors

Adrenergic agonist: Nasal decongestants only

Phenylpropanolamine, Pseudoephedrine

Adrenergic agonist: causes hemolytic anemia, thereby (+) in Coomb's test

Methyldopa

Adrenergic antagonist: For HTN pt with increased PVR (due to additional alpha-blockade)

Labetalol, carvedilol

Class: methoxamine

Alpha 1 agonist

SABA/LABA: Salmeterol

LABA

SABA/LABA: Formoterol

LABA

Class: isoproterenol

Beta 1 and 2 agonist

Class: Tyramine

Indirect acting adrenergic agonist

Class: Methylphenidate

Indirect acting adrenergic agonist

Class: Amphetamine

Indirect acting adrenergic agonist

Class: Phentermine

Indirect acting adrenergic agonist

Class: -zosins

Alpha 1 blocker

Class: yohimbine

Alpha 2 blocker

Class: phenoxybenzamine

Alpha 1 and 2 blocker

Class: phentolamine

Alpha 1 and 2 blocker

Class: Nadolol

Non-selective Beta Blocker

Class: Sotalol

Non-selective Beta Blocker

Class: Propanolol

Non-selective Beta Blocker

Most cardioselective beta blocker

Nebivolol

Selective BBs with partial agonist activity - with ISA activity (6)

- acebutolol

- celiprolol

- penbutolol

- pindolol

- labetalol

- carteolol

Combined alpha and beta blockers (2)

- labetalol

- carvedilol

Class: bethanecol

Ditect acting cholinergic agonist

Class: carbachol

Ditect acting cholinergic agonist

Class: metacholine

Ditect acting cholinergic agonist

Class: muscarine

Ditect acting cholinergic agonist

Class: pilocarpine

Ditect acting cholinergic agonist

Class: edrophonium

Indirect acting cholinergic agonist

Class: -stigmines

Indirect acting cholinergic agonist

Class: carbaryl, methylcarbamate

Indirect acting cholinergic agonist

Class: isofluorophate, echothiophate

Indirect acting cholinergic agonist

Class: malathion, parathion

Indirect acting cholinergic agonist

Class: tabun, sabin, soman

Indirect acting cholinergic agonist

Class: nicotine

Ganglionic blocker

Class: lobeline

Ganglionic blocker

Class: hexamethonium

Ganglionic blocker

Class: mecamylamine

Ganglionic blocker

Class: trimethapam

Ganglionic blocker

Class: -cura-

Non depolarizing Neuromuscular blocker

Class: succinylcholine or suxamethonium

Depolarizing neuromuscular blocker

Prototype cholinergic agonist

Acetylcholine

Cholinergic agonist: Used as eye drops in ophthalmology to constrict the pupil; used to treat glaucoma (3)

Acetylcholine, Carbachol, Pilocarpine

Cholinergic agonist: negative chronotropy, decrease BP

Acetylcholine

Parasympathetic Drugs side effect

DUMBELS

- diarrhea

- urination

- miosis

- bradycardia

- emesis

- lacrimation

- salivation

Cholinergic agonist: not hydrolyzed by AChE (2)

Bethanechol, Carbachol

Cholinergic agonist: Increase intestinal motility after surgery (bowel)

Bethanechol

Cholinergic agonist: Causes urinary retention

Bethanechol

Cholinergic agonist: For dx of asthma (as it causes bronchoconstriction)

Methacholine

Cholinergic agonist: tertiary amine, stable to hydrolysis by AChE

Pilocarpine

Cholinergic agonist: DOC for emergency lowering of intraocular pressure

Pilocarpine

Cholinergic agonist: S/E - enters CNS, causes hallucinations, seizures, DUMBELS

Pilocarpine

Cholinergic drugs that bind to Ach receptor and prevent Ach binding

Direct-acting

Cholinergic drugs that inhibit AChE

Indirect-acting

Indirect-acting cholinergic agonist - short duration

Quaternary amine

Brand: Tensilon

Edrophonium

Cholinergic agonist: prototype short-acting AChE inhibitor

Edrophonium

Cholinergic agonist: Dx of myasthenia gravis

Edrophonium

Cholinergic agonist: Binds reversibly to the active center of AChE, preventing hydrolysis of Ach

Edrophonium

Indirect-acting cholinergic agonist - intermediate duration

Carbamates

Cholinergic agonist: AKA eserine

Physostigmine

Cholinergic agonist: forms a stable intermediate with AChE, reversibly inactivated

Physostigmine

Cholinergic agonist: Tx of intestinal and bowel atony, glaucoma

Physostigmine

Cholinergic agonist: Antidote for anticholinergic poisoning

Physostigmine

Physostigmine is the antidote for poisoning of which anticholinergics?

Atropine, phenothiazine, TCAs

Cholinergic agonist: Tx of myasthenia gravis (2)

Neostigmine, Pyridostigmine

Cholinergic agonist: Antidote for tubocurarine poisoning (neuromuscular / nicotinic blocker)

Neostigmine

Brand: Mestinon

Pyridostigmine

Carbamate insecticides (2)

Carbaryl, methylcarbamate