Oc Pharm 1 (Orbital aesthetics/cosmetics)

What medication is an insulin-like growth factor-1 receptor antagonist used in the treatment of thyroid eye disease?

Tepezza

What are ADRs associated with Tepezza?

hearing loss and alopecia

What medication is an example of an acetylcholine release inhibitor and a neuromuscular junction blocking agent?

Botox

What are contraindications to botox?

known hypersensitivity, infection at the injection site, pre-existing cardiovascular disease

What are ADRs of botox?

spread of toxin effects (difficulty breathing/swallowing)

What is a side effect of botox at the lateral canthal lines?

lid edema

What is a side effect of botox at the lateral forehead lines?

headaches and brow ptosis

What is an alpha-adrenergic receptor agonist used for the treatment of acquired blepharoptosis?

Upneeq (oxymetazoline 0.1%)

What does Upneeq (oxymetazoline 0.1%) selectively target?

Mueller muscle

What are warnings/precautions associated with Upneeq (oxymetazoline 0.1%)?

ptosis can be a sign of severe neurologic disease, impacts on cardiovascular disease, potential for vascular insufficiency, risk of angle closure glaucoma

What is a prostaglandin analog used to treat hypotrichosis of the eyelashes to increase their growth?

Latisse (bimatoprost 0.03%)

What is an ADR associated with Latisse (bimatoprost 0.03%)?

pigmentation of eyelids and iris may occur (iris changes are permanent)

What is a can the use of Latisse (bimatoprost 0.03%) along side another prostaglandin analog lead to?

further decreased IOP (hypotonia of eye)